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Table 1 Non-vascular disease processes producing some of the clinical picture akin to a stroke

From: Methyl iodide poisoning presenting as a mimic of acute stroke: a case report

Conditions Comments
A. Nervous system
Epilepsy Todd's palsy presents with postictal confusion, transient focal motor and sensory symptoms, extra-ocular movement deficits; witness and/or history is important and has a resolving course.
Hemiplegic migraine [4] Headache, impaired consciousness, ataxia and hemi paresis; stereotypical attacks can occur.
Infection(meningitis/encephalitis/abscess) Headache, hemiparesis, altered consciousness; systemic disturbances common
Intracranial mass lesions [14] Subdural hematoma, tumors and abscesses can present with headache and abrupt onset focal neurological symptoms. Fever, weight loss, systemic disturbances are common.
Encephalopathy Can present with altered behavior, cognition, coma, aphasia, focal motor and sensory deficits, homonymous hemianopia and hemi hyperreflexia.
Multiple sclerosis Visual and long tract neurological symptoms; recurrences of neurological deficits in space and time are common.
Myasthenia gravis (rare) Ocular myasthenia and weakness mimic stroke; variable and diurnal fluctuation.
B. Non-nervous system
Syncope Usually due to hypotension or arrhythmia; Vertebrobasilar insufficiency can cause syncope.
Sepsis Various neurological presentations, systemic disturbances common
Hyponatremia, hyperglycemia, hypoglycemia [5] Can present with fluctuating neurological symptoms, aphasia, cortical blindness and so on; an initial blood sugar check is vital.
Functional disorders Conversion disorders can have hemiparesis, blindness, speech disturbances; psychiatric history
Industrial toxins, drug overdose Conversion disorders can have hemiparesis, blindness, speech disturbances; psychiatric history