Figure 4

Changes in T-ALP level, uNTX level, and bone pain (VAS) after the treatment with low-dose alendornate for six months (Patient 2). (A) T-ALP and (B) uNTX levels returned to normal range and, (C) bone pain (VAS) disappeared within six months. These remissions continued throughout the 1.5 to 2 years since the discontinuation of the treatment, although T-ALP and uNTX levels were slightly elevated above the normal range and was accompanied with mild bone pain. A resumption of alendronate treatment rapidly decreased the levels of (A) T-ALP and (B) uNTX, and (C) improved bone pain. T-ALP (IU/l), serum total alkaline phosphatase; uNTX (nMBCE/mM·CR), urinary N-terminal telopeptide of type I collagen; VAS, visual analogue scale; T, duration of the treatment with alendronate (0 to 6, 30 to 36, and 48 to 54 months.)