Spleen at autopsy. (A) Multiple tumor nodules efface the normal splenic architecture (hematoxylin and eosin, ×100). (B) The tumor nodules consist of clusters of numerous bizarre multinucleated tumor giant cells with irregular nuclei and coarse chromatin (hematoxylin and eosin, ×400). (C) Occasional classic Reed-Sternberg like tumor cells with macronucleoli are also present (hematoxylin and eosin, ×1000). (D) An immunostain for CD30 highlights the majority of the tumor giant cells (×100).