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Table 1 Substances used in intradermal testing

From: Successful desensitization with human insulin in a patient with an insulin allergy and hypersensitivity to protamine: a case report

  Substance 20 minutes 24 hours 48 hours
1 Levemir © (insulin glargine, m-cresol, glycerol) + ++ ++
2 Huminsulin basal © (human insulin, m-cresol, phenol, glycerol, protamine) + ++ ++
3 Lantus © (insulin glargine, m-cresol, glycerol) + ++ ++
4 Actrapid penfill © (human insulin, m-cresol, glycerol) + ++ ++
5 Insuman rapid © (human insulin, m-cresol) + ++ ++
6 Berlinsulin H normal © (human insulin, phenol, protamine, glycerol) + ++ ++
7 Insulin Novo semilente © (porcine insulin, methyl-4-hydroxybenzoate, natrium acetate) + ++ ++
8 Humalog © (insulin lispro, m-cresol, glycerol, NaH2PO4 × H2O, zinc oxide) + + +
9 Novorapid © (insulin aspart, glycerol, m-cresol, phenol, NaH2PO4 × H2O) + + +
10 Apidra © (insulin glulisine, m-cresol, trometamol, polysorbate 20) + + +
11 Test solution A (NaH2PO4 × H2O 2.1 mg, glycerol 85% 18.8 mg, phenol 0.6 mg, m-cresol 1.5 mg in aqua dest. ad 1.0 ml) - - -
12 Test solution B (glycerol 85% 18.8 mg, phenol 0.6 mg, m-cresol 1.5 mg in aqua dest. ad 1.0 ml) - - -
13 Test solution C (phenol 0.6 mg, m-cresol 1.5 mg in aqua dest. ad 1.0 ml) + - -
14 Test solution D (phenol 0.6 mg in aqua dest. ad 1.0 ml) + - -
15 Test solution E (m-cresol 1.5 mg in aqua dest. ad 1.0 ml) + - -
16 Test solution F (protamine 0.1 mg, NaH2PO4 × H2O 2.1 mg, glycerol 85% 18.8 mg, phenol 0.6 mg, m-cresol 1.5 mg in aqua dest. ad 1.0 ml) + ++ ++
17 Test solution G (protamine 0.1 mg in aqua dest. ad 1.0 ml) - ++ ++
18 Test solution H (zinc chloride 0.06 mg, glycerol 85% 20 mg, m-cresol 2.7 mg in aqua dest. ad 1.0 ml) - - -
19 Test solution I (glycerol 85% 20 mg, m-cresol 2.7 mg in aqua dest. ad 1.0 ml) - - -
20 Test solution J (m-cresol 2.7 mg in aqua dest. ad 1.0 ml) - - -
21 Aqua dest. - - -
22 NaCl 0.9% - - -
23 Histamine 0.01% + - -
  1. Test solutions A-J were obtained from the Sanofi Aventis Insuman© test kit. Test results were noted 20 minutes, 24 hours, and 48 hours after injection. Interpretation of test results: -, no skin reaction; +, erythema and infiltrate with a diameter of <20 mm; ++, erythema and infiltrate with a diameter of >20 mm.