Table 1 Endocrine evaluation of the patient at 14 and 20 years of age

Skeletal age (years)

10

Closed epiphysis

Weight (kg)

25.7

39.8

Height (m)

1.19

1.41

FSH levels (mIU/ml),

(Basal/peak response to LHRH stimulation)

0.90/4.90

9.27/11.6

LH levels (mIU/ml),

(Basal/peak response to LHRH stimulation)

0.70/9.70

9.57/50.9

Estradiol levels (pg/ml),

(Basal/to LHRH stimulated response)

5/20

31.1/315.0

GH levels (ng/ml),

(Basal/peak response to L-Dopa stimulation, following estradiol priming)

0.93/6.10

-

GH levels (ng/ml),

(Basal/peak response to insulin-induced hypoglycemia when the lowest glucose was 26 mg/dl))

-

0.37/5.18

Overnight GH profile (ng/ml),

(Frequent sampling from 10 00 pm to 10 00 am)

-

0.07/0.12/0.37/0.11/0.05/0.24

IGFBP3(ng/ml)

2941

-

Basal IGF1 (ng/ml)

17.5

50.8

TSH levels (mU/ml),

(Basal/peak response to TRH stimulation)

4.6/14.5

4.57/21.97

Basal FT4 (pmol/l)

16.7

12.71

Cortisol levels (μg/dl)

(Basal/peak response to insulin-induced hypoglycemia)

-

9.9/20.2