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Table 1 Endocrine evaluation of the patient at 14 and 20 years of age

From: Pituitary hypoplasia and growth hormone deficiency in a woman with glycogen storage disease type Ia: a case report

Age (years) 14 20
Skeletal age (years) 10 Closed epiphysis
Weight (kg) 25.7 39.8
Height (m) 1.19 1.41
FSH levels (mIU/ml), (Basal/peak response to LHRH stimulation) 0.90/4.90 9.27/11.6
LH levels (mIU/ml), (Basal/peak response to LHRH stimulation) 0.70/9.70 9.57/50.9
Estradiol levels (pg/ml), (Basal/to LHRH stimulated response) 5/20 31.1/315.0
GH levels (ng/ml), (Basal/peak response to L-Dopa stimulation, following estradiol priming) 0.93/6.10 -
GH levels (ng/ml), (Basal/peak response to insulin-induced hypoglycemia when the lowest glucose was 26 mg/dl)) - 0.37/5.18
Overnight GH profile (ng/ml), (Frequent sampling from 10 00 pm to 10 00 am) - 0.07/0.12/0.37/0.11/0.05/0.24
IGFBP3(ng/ml) 2941 -
Basal IGF1 (ng/ml) 17.5 50.8
TSH levels (mU/ml), (Basal/peak response to TRH stimulation) 4.6/14.5 4.57/21.97
Basal FT4 (pmol/l) 16.7 12.71
Cortisol levels (μg/dl) (Basal/peak response to insulin-induced hypoglycemia) - 9.9/20.2
  1. Normal values for basal growth hormone (GH): 0 to 7 ng/ml; insulin-like growth factor1 (IGF1), for 12- to 15-year-old girls: 261 to 1096 ng/ml, for 16- to 24-year-old women: 182 to 780 ng/ml; insulin-like growth factor binding protein 3 (IGFBP3), for 7 to 39 year olds: 1250 to 7330 ng/ml; normal GH response to insulin-induced hypoglycemia >5.0 ng/ml; severe GH deficiency in insulin-induced hypoglycemia <3.0 ng/ml; normal GH response to L-Dopa >10 ng/ml.