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Table 1 Hemodynamic and pulmonary parameters

From: Phosphodiesterase 5 inhibitors lower both portal and pulmonary pressure in portopulmonary hypertension: a case report

   After 3 months Sildenafil After 6 months Sildenafil
Parameter Baseline After 60 minutes Tadalafil 60 min after the last dose 8 h after the last dose 60 min after 20 mg Sildenafil
Systolic BP (mmHg) 167 159 147 145 140
Diastolic BP (mmHg) 89 86 97 100 90
Heart rate (1/min) 75 87 93 69 75
Cardiac index (l/minm2) 3.02 3.51   3.33 3.56
Cardiac output (l/min) 6.8 7.9   7.5 8.0
Mean PAP (mmHg) 45 39   42 42
PVR (dyn·s-1·cm-5) 459 344   352 360
Central venous pressure (mmHg) 3 3   6 3
PAWP 6 6   9 6
Hepatovenous pressure gradient (mmHg) 10 7   10  
Arterial paO2 (mmHg) 70.5 78.2 71.4 76.9  
Arterial paCO2 (mmHg) 41.3 38.4 35.3 31.3  
6 min walking test (m) 522   514 580  
VO2peak (ml/min) 2020 2240   2640  
Watt max 120 130   140  
VE/VO2 37.0 33.5   29.3  
VE/VCO2 35.2 33.2   27.8  
  1. Hemodynamic and pulmonary parameters after inhibition of PDE5. BP = blood pressure, PAP = pulmonary arterial pressure, PVR = pulmonary vascular resistance, VO2peak = peak oxygen uptake, VE/VO2 ventilatory equivalent of oxygen; VE/VCO2 ventilatory equivalent of carbon dioxide. PAWP = pulmonary arterial wedged pressure