Phosphodiesterase 5 inhibitors lower both portal and pulmonary pressure in portopulmonary hypertension: a case report

Table 1 Hemodynamic and pulmonary parameters

		After 3 months Sildenafil		After 6 months Sildenafil
Parameter	Baseline	After 60 minutes Tadalafil	60 min after the last dose	8 h after the last dose	60 min after 20 mg Sildenafil
Systolic BP (mmHg)	167	159	147	145	140
Diastolic BP (mmHg)	89	86	97	100	90
Heart rate (1/min)	75	87	93	69	75
Cardiac index (l/minm²)	3.02	3.51		3.33	3.56
Cardiac output (l/min)	6.8	7.9		7.5	8.0
Mean PAP (mmHg)	45	39		42	42
PVR (dyn·s^-1·cm^-5)	459	344		352	360
Central venous pressure (mmHg)	3	3		6	3
PAWP	6	6		9	6
Hepatovenous pressure gradient (mmHg)	10	7		10
Arterial p_aO₂ (mmHg)	70.5	78.2	71.4	76.9
Arterial p_aCO₂ (mmHg)	41.3	38.4	35.3	31.3
6 min walking test (m)	522		514	580
VO_2peak (ml/min)	2020	2240		2640
Watt max	120	130		140
VE/VO₂	37.0	33.5		29.3
VE/VCO₂	35.2	33.2		27.8

Hemodynamic and pulmonary parameters after inhibition of PDE5. BP = blood pressure, PAP = pulmonary arterial pressure, PVR = pulmonary vascular resistance, VO_2peak = peak oxygen uptake, VE/VO₂ ventilatory equivalent of oxygen; VE/VCO₂ ventilatory equivalent of carbon dioxide. PAWP = pulmonary arterial wedged pressure

ISSN: 1752-1947