Verapamil-associated cardiogenic shock in a 71-year-old man with myasthenia gravis: a case report
© Drolet et al; licensee Cases Network Ltd. 2009
Received: 2 May 2008
Accepted: 23 January 2009
Published: 16 June 2009
Myasthenia gravis is a rare neuromuscular disorder associated with a reduction in the availability of acetylcholine receptors at the post-synaptic membranes of skeletal muscles. This is caused by the production of anti-acetylcholine receptor antibodies at the neuromuscular junction due to an autoimmune insult, leading to a compromised neuromuscular transmission. Verapamil can influence, in a dose-dependent fashion, the neuromuscular transmission in myasthenia gravis.
We report a 71-year-old Caucasian man with myasthenia gravis suffering from a cardiogenic shock following a single dose of verapamil. The patient had uncontrolled atrial fibrillation with a heart rate of 120 beats/min. Atenolol 100 mg was started. The next day, verapamil SR 240 mg was started. Two hours after the first dose of verapamil, the patient complained of weakness and dyspnea with signs of shock; his blood pressure was 70/50 mm Hg and heart rate at 101 beats/min. An echocardiogram showed diffuse hypokinesis of both ventricles with an ejection fraction of 20%. Cardiac catheterization was performed and coronary arteries appeared without significant stenosis, but there was a diffuse hypokinesis. Verapamil was stopped and the patient received intravenous glucagon and calcium chloride. Both the anti-acetylcholine receptor and anti-striated muscle antibodies tested positive. A few hours later, another echocardiogram showed an improvement in the ventricular function, which returned to normal five days later.
Caution is needed when administering verapamil to patients with myasthenia gravis, especially when the anti-acetylcholine receptor and anti-striated muscle antibodies titres are positive.
Myasthenia gravis (MG) is a rare (4 cases/100,000 individuals) neuromuscular disorder characterized by weakness and excessive fatigability of skeletal muscles following repetitive effort and slow recovery after exercise . The defect in MG is a reduction in the availability of acetylcholine receptors at the post-synaptic membranes of skeletal muscles. This is caused by the production of anti-acetylcholine receptor antibodies (AchR-Ab) at the neuromuscular junction (NMJ) due to an auto-immune insult , leading to compromised neuromuscular transmission (NMT). Verapamil is a calcium channel blocker useful in lowering blood pressure and in slowing cardiac atrioventricular conduction. It can also affect, in a dose-dependent fashion, the NMT in MG . Verapamil's most commonly reported adverse effects are constipation, dizziness and nausea. We describe a patient with known MG who experienced cardiogenic shock following administration of a dose of verapamil.
Classes of drugs known to exacerbate Myasthenia Gravis
Antibiotics (aminoglycosides, polypeptides, tetracyclines)
Quinine and related drugs
Cardiovascular drugs: beta-blockers, procainamide, quinidine
The calcium channel blocker (CCB) verapamil is useful in the treatment of recurrent supraventricular arrhythmias. It blocks the slow calcium ion influx into contractile and conduction fibres, prolongs the refractory period in nodal cells and may also depress contractility . Respiratory failure immediately following intravenous injection of verapamil has been reported in a patient with Duchenne's dystrophy . This suggests that verapamil might exacerbate muscle weakness when NMT is impaired. Drug-induced neuromuscular blockade is uncommon in subjects without MG, presumably because of the high safety margin for neuromuscular transmission that exists under normal circumstances.
Previous studies evaluating the effects of CCBs on the NMT showed that these agents impair transmission in the NMJ, especially in conjunction with a second neuromuscular blocking agent . The safety margin for functional NMT was reported to be as high as 80% to 90% blockade of all post-junction receptors . It was reported that MG muscle showed a 70% to 89% reduction in the number of acetylcholine receptors per neuromuscular junction, compared to the control muscle , thus strongly suggesting that verapamil can affect NMT in individuals with MG at subclinical doses. In other words, the deleterious neuromuscular action of verapamil in MG is unmasked by the narrow safety margin resulting in a reduction in "receptor reserve". Similarly, verapamil-induced aggravation of Lambert-Eaton myasthenic syndrome has also been described . This might be a consequence of the effect on voltage-dependent calcium channels involved in the release of acetylcholine at the presynaptic nerve terminal, the probable target of the immune response leading to Lambert-Eaton syndrome (LES) .
Indeed, worsening of muscle weakness upon exposure to verapamil has clearly been demonstrated in disorders of NMT such as MG and LES . Moreover, it was suggested that this phenomenon is exacerbated when AchR-Ab and antistriated muscle antibodies are positive. In our patient, the measurement of AchR-Ab was positive at 0.23 nmol/L (normal ≤0.02 nmol/L) and antistriated muscle antibodies were also positive at 1:3840 (normal <1:60); the time course of clinical deterioration pointed to verapamil as the responsible drug. This hypothesis is supported given that not only did the patient begin complaining of weakness and dyspnea within 2 hours of the first and only verapamil dose, but he also presented with signs of cardiogenic shock with blood pressure of 70/50 mm Hg and a heart rate of 101 beat/min. A posteriori, verapamil appears as the likely "missing link" between these apparently unrelated symptoms. Indeed, bradycardia, transient asystole and exacerbation of heart failure have been reported with verapamil, although these responses usually occurred after intravenous administration of the drug or in the presence of β-adrenergic receptor blockade [6, 12]. In this case, oral verapamil was added to atenolol, potentially contributing to further acute myocardial hemodynamic depression, as it has been frequently reported in the past [6, 12]. However, if further cardiac deterioration upon exposure to verapamil was solely due to its calcium channel blocking properties, it should have been observed before, while the patient was on a combined metoprolol and diltiazem regimen. In fact, in this case, a few minutes before the cardiogenic shock, a pacemaker-induced sinus rhythm was recorded and spectacular widening of the QRS (230 msec) was observed (Figure 1A), suggesting further deterioration of cardiac conduction upon exposure to verapamil. Interestingly, in addition to its calcium channel-blocking properties, and unlike diltiazem, verapamil has been reported to block both the fast and late cardiac sodium currents [13, 14]. In a patient such as ours, for whom calcium-dependent depolarization is compromised, conduction capacity strongly relies on the cardiac sodium current (INa). It is therefore likely that verapamil, with its INa-blocking effect, depleted the "vital conduction reserve" of this patient, leading to cardiac decompensation and shock. It is noteworthy that this has never been observed with diltiazem before due to lack of INa-blocking influence. QRS narrowing following verapamil withdrawal and administration of calcium chloride and glucagon (Figure 1B) is also consistent with this explanation. Nevertheless, one could argue that diltiazem is also a CCB known to affect the NMT. However, our patient had been treated safely with this drug, well before the onset of the cardiac deterioration. Moreover, as the elimination half-life of diltiazem is estimated at 5 hours, and as verapamil was initiated more than 24 hours after diltiazem cessation, approximately 5 half-lives, it appears unlikely that a significant combined calcium channel blocking action of both drugs was responsible for the patient's neuromuscular and cardiac deterioration.
Another possible explanation for the clinically observed rapid hemodynamic deterioration of this patient was the development of Takotsubo syndrome. Takotsubo cardiomyopathy, also known as transient apical ballooning or apical ballooning cardiomyopathy, is a type of nonischemic cardiomyopathy in which there is a sudden temporary weakening of the myocardium . The typical presentation of someone with Takotsubo cardiomyopathy is sudden onset of congestive heart failure or chest pain associated with ECG changes suggestive of an anterior wall heart attack. During the course of evaluation of the patient, a bulging out of the left ventricular apex with a normo- or hypercontractile base of the left ventricle is considered the hallmark of this syndrome. Indeed, the diagnosis is made by the pathognomic wall motion abnormalities, in which the base of the left ventricle is contracting normally or is hyperkinetic while the remainder of the left ventricle is akinetic or dyskinetic. This is accompanied by the lack of significant coronary artery disease that could explain the wall motion abnormalities. Provided that the individual survives the initial presentation, the left ventricular function improves within 2 months.
An argument against the Takotsubo syndrome hypothesis in this case is the fact that hypokinesis was shown to be diffuse and in both ventricles. Bulging of the apex was never observed. Moreover, only a few hours after verapamil withdrawal, ventricular function improved. Five days later, the ejection fraction returned to normal as well as the patient's electrocardiogram.
We described a patient with known MG with cardiogenic shock following administration of verapamil, a drug known to cause a deleterious impact on the NMT. This case strongly suggests that caution is needed when administering verapamil or other CCBs to MG patients with impaired NMT, especially when AchR-Ab and the antistriated muscle antibodies titres are positive.
Written informed consent was obtained from the patient's wife for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
Calcium channel blocker
- INa :
cardiac sodium current
Benoit Drolet is the recipient of a New Investigator Scholarship Award from the Heart and Stroke Foundation of Canada. Chantale Simard and Paul Poirier are recipients of Chercheur-boursier clinicien Scholarship Awards from the Fonds de la recherche en santé du Québec.
- Pina Latorre MA, Cobeta JC, Rodilla F, Navarro N, Zabala S: Influence of calcium antagonist drugs in myasthenia gravis in the elderly. J Clin Pharm Ther. 1998, 23: 399-401. 10.1046/j.1365-2710.1998.00172.x.View ArticlePubMedGoogle Scholar
- Seybold ME: Myasthenia gravis. A clinical and basic science review. JAMA. 1983, 250: 2516-2521. 10.1001/jama.250.18.2516.View ArticlePubMedGoogle Scholar
- Swash M, Ingram DA: Adverse effect of verapamil in myasthenia gravis. Muscle Nerve. 1992, 15: 396-398. 10.1002/mus.880150321.View ArticlePubMedGoogle Scholar
- Russell DS: Histological changes in the striped muscles in myasthenia gravis. J Pathol Bacteriol. 1953, 65: 279-289. 10.1002/path.1700650202.View ArticlePubMedGoogle Scholar
- Whitaker JN: Myasthenia gravis and autoimmunity. Adv Intern Med. 1980, 26: 489-510.PubMedGoogle Scholar
- Henry M, Kay MM, Viccellio P: Cardiogenic shock associated with calcium-channel and beta blockers: reversal with intravenous calcium chloride. Am J Emerg Med. 1985, 3: 334-336. 10.1016/0735-6757(85)90060-9.View ArticlePubMedGoogle Scholar
- Zalman F, Perloff JK, Durant NN, Campion DS: Acute respiratory failure following intravenous verapamil in Duchenne's muscular dystrophy. Am Heart J. 1983, 105: 510-511. 10.1016/0002-8703(83)90371-X.View ArticlePubMedGoogle Scholar
- Kraynack BJ, Lawson NW, Gintautas J: Neuromuscular blocking action of verapamil in cats. Can Anaesth Soc J. 1983, 30: 242-247. 10.1007/BF03013802.View ArticlePubMedGoogle Scholar
- Waud BE, Waud DR: The margin of safety of neuromuscular transmission in the muscle of the diaphragm. Anesthesiology. 1972, 37: 417-422. 10.1097/00000542-197210000-00012.View ArticlePubMedGoogle Scholar
- Drachman DB, Kao I, Pestronk A, Toyka KV: Myasthenia gravis as a receptor disorder. Ann N Y Acad Sci. 1976, 274: 226-234. 10.1111/j.1749-6632.1976.tb47688.x.View ArticlePubMedGoogle Scholar
- Krendel DA, Hopkins LC: Adverse effect of verapamil in a patient with the Lambert-Eaton syndrome. Muscle Nerve. 1986, 9: 519-522. 10.1002/mus.880090607.View ArticlePubMedGoogle Scholar
- Motte G, Bellanger P, Vogel M, Belhassen B, Welti JJ: Asystole followed by cardiogenic shock after intravenous injection of verapamil. Ann Cardiol Angeiol (Paris). 1975, 24: 157-162.Google Scholar
- Carmeliet E: Selectivity of antiarrhythmic drugs and ionic channels: a historical overview. Ann N Y Acad Sci. 1984, 427: 1-15. 10.1111/j.1749-6632.1984.tb20771.x.View ArticlePubMedGoogle Scholar
- Fish JM, Welchons DR, Kim YS, Lee SH, Ho WK, Antzelevitch C: Dimethyl lithospermate B, an extract of Danshen, suppresses arrhythmogenesis associated with the Brugada syndrome. Circulation. 2006, 113: 1393-1400. 10.1161/CIRCULATIONAHA.105.601690.View ArticlePubMedPubMed CentralGoogle Scholar
- Gianni M, Dentali F, Grandi AM, Sumner G, Hiralal R, Lonn E: Apical ballooning syndrome or takotsubo cardiomyopathy: a systematic review. Eur Heart J. 2006, 27: 1523-1529. 10.1093/eurheartj/ehl032.View ArticlePubMedGoogle Scholar
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