Fig. 2

A Abnormal karyotype of the harvested spinal ependymoma shows a derivative chromothriptic chromosome 6, extra copy of chromosome 7, and loss of chromosome 22 in 80% of the examined cells. B Whole genome ThermoFisher SNP microarray from FFPE tumor confirms gain of chromosome 7, loss of chromosome 22, and numerous regions with copy number losses over the entire chromosome 6. C Close up examination of chromosome 6 shows chromothripsis spanning from pter to qter and involving more than 100 breakpoints. A–B allele frequency track appears as 5 tracks with the log₂ ratio falling slightly below 2. Upon close inspection (green boxed region), it appears that the A–B allele track represents alternating regions, with three and two tracks consistent with normal and deleted regions, respectively