A giant squamous cell carcinoma of the skin of the thoracic wall: a case report and review of the literature
© The Author(s). 2017
Received: 11 January 2017
Accepted: 30 March 2017
Published: 11 May 2017
We report a case of a 48-year-old white woman who presented with a huge cutaneous protruding tumor of the thoracic wall below her left breast.
The lesion was excised with clear margins from the adjacent skin, and subcutaneous tissue was left to heal with second intention. A histological examination of the surgical specimen revealed a well-differentiated infiltrative cutaneous squamous cell carcinoma. Our patient neglected to attend our Oncological Department to receive chemotherapy. Today, 12 months after surgery, she is alive and without evidence of disease recurrence.
Cutaneous squamous cell carcinoma can reach a huge size if left untreated. Surgery is the primary mode of treatment, followed by chemotherapy if applicable.
KeywordsSquamous Carcinoma Cutaneous Invasion Metastasis
Squamous cell carcinoma (SCC) of the skin is the second most common type of skin cancer and is steadily increasing in frequency [1, 2]. Although most cutaneous SCCs are diagnosed early and successfully treated, in a small percentage of cases, especially if neglected, they may obtain uncontrollable growth and substantial disfigurement. These cases with giant cutaneous SCCs (maximum diameter >5 cm) can be very difficult to treat and despite aggressive excision can present with recurrence and/or metastases.
Here we present a case with a huge cutaneous tumor on the thoracic wall below the left breast that was excised with optimal clinical result.
A full blood count and biochemistry were normal and a total body computed tomography (CT) scan of her thoracic wall showed that the tumor had not infiltrated deep into the musculoskeletal layers of her thoracic wall.
After surgery her condition significantly improved. The wound was taken care of daily and she was discharged home after 2 weeks. The wound healed gradually within a couple of months.
Our patient was advised to go to the Oncological Department of our hospital to receive chemotherapy, which she neglected to do. At present, 12 months after surgery, she remains in good condition, with excellent quality of life and a CT scan showing no evidence of disease recurrence.
Cutaneous SCCs are often associated with radiation exposure, burn scars, varicose ulcers, human papilloma virus infection, chronic inflammation, chronic infection, chemical carcinogens, immunosuppression, and several genetic syndromes . There is also evidence that they may be associated with psoriasis vulgaris; both diseases express bax (bcl-2-associated protein) immunoreactivity . In fact, there have been a few reports of SCCs arising on the grounds of psoriasis vulgaris or lupus vulgaris [7, 8].
The most usual site of giant epithelial malignancies (basal cell carcinoma, SCC) is the scalp [9, 10]. There are, however, cases with other locations, mainly exposed to sun radiation, such as the face and the ear lobes. In any location, they progressively enlarge by peripheral extension or vertical infiltration of the underlying tissue . The most frequent causes of a delay in diagnosis are: low social status, poor personal hygiene, and fear of the diagnosis and the possible consequences . Our patient had all three above causes contributing to the delay in diagnosis and she had a psychiatric disorder. There are not enough data in the literature indicating a possible correlation between neglected tumors and psychiatric disorders, and patient embarrassment seems to be a substantial obstacle, especially in patients with low social status and an underlying psychiatric disorder, as was the case in our patient .
Localized SCC of the skin is considered a curable disease. In the case of giant tumors (maximum diameter >5 cm) CT or magnetic resonance imaging (MRI) may be required to accurately assess the extent of the tumor and the possible presence of lymphatic spread . The recommended methods of treatment involve simple excision, cryosurgery, radiation therapy, electrodessication, and curettage . Giant SCC fulfills the criteria of high risk skin carcinomas. Primary treatment is surgical with meticulous examination of the excision margins to ensure R0 resection . For the defect closure, various musculocutaneous flaps and skin transplants have been used. However, the surgical wound can be left open to close gradually with second intention. Surgery is the treatment of choice and the most effective means of achieving cure of any invasive SCC, as it allows confirmation of the tumor type, stage, and examination of the tumor-free status of the resection margins . Complete surgical excision provides very high rates of local control with cure rates of 95% . Other destructive or topical techniques, such as cryotherapy, radiotherapy, curettage, and electrodessication, are reserved for old debilitated patients or for patients who refuse to undergo surgery. After surgery, polychemotherapy is used with cisplatin, 5-fluoruracil, paclitaxel, methotrexate, and other agents with moderate results in cases of advanced inoperable disease . Targeted therapy with epidermal growth factor receptor (EGFR) inhibitors such as cetuximab or erlotinib, are second-line options after monochemotherapy or polychemotherapy failure and disease progression .
Follow-up is very important in the management of these tumors, as almost 30 to 50% of patients with SCC are at risk of developing another tumor within 5 years after surgery. Of interest, the majority of these recurrences will develop within 2 years of the initial operation. For that reason, a close follow-up, such as every 6 months, should be applied in patients with resected SCCs, especially for neglected ones with enormous size.
Localized squamous cell cancer of the skin can reach enormous size if neglected. The invasiveness of the tumor depends on the size, anatomical location, and histological subtype. Surgery is the mainstay of treatment even in giant tumors followed by chemotherapy for the risk of metastatic spread.
No funds were necessary for this study.
Availability of data and materials
Material and data are the contents of the medical file of the patient. The histopathological pictures were provided by Dr Vasileia Damaskou from the Department of Pathology of our hospital.
EM is the chief surgeon of this case and the main author of this case report. PP helped him in this operation and contributed in the collection and interpretation of data. NZ is a pediatric surgeon in our Department and contributed in analyzing the patient’s clinical reports, literature review, and obtaining informed consent of the patient. AM is the Chairman of our Department; he provided mentorship, guidance, and contributed in editing this case report. VD is the pathologist who studied the surgical specimen of this patient; ARG is a resident in Pathology who helped her in the histological study. They both provided us with the histopathological pictures for this case report and wrote the Pathology part in the Case presentation section. AK, an oncologist in our hospital, studied this case from the Oncology point of view and performed the stage analysis for this patient. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
Consent for publication
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
Ethics approval and consent to participate
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Jennings L, Schmults CD. Management of high-risk cutaneous squamous cell carcinoma. J Clin Aesthet Dermatol. 2010;3:39–48.PubMedPubMed CentralGoogle Scholar
- Hugh M, Gloster Jr HM, Neal K. Skin cancer in skin of color. J Am Acad Dermatol. 2006;55:741–60.View ArticleGoogle Scholar
- Edge S, Byrd DR, Compton CC, Fritz AG, Greene FL, editors. AJCC Cancer Staging Manual. 7th ed. New York: Springer; 2010.Google Scholar
- Miller SJ, Alam M, Andersen J, et al. Basal cell and squamous cell skin cancers. J Natl Compr Canc Netw. 2010;8:836–864.Google Scholar
- Kuma Y, Ito T, Nagae K, et al. Two cases of cutaneous squamous cell carcinoma arising in immunosuppressed patients with chronic human papillomavirus infection. Case Rep Dermatol. 2015;7:178–82.View ArticlePubMedPubMed CentralGoogle Scholar
- Tokmova H, Fujimoto W, Arata J. Expression of the bcl-2 homologue bax in normal human skin, psoriasis vulgaris and non-melanoma skin cancers. Eur J Dermatol. 1998;8:256–60.Google Scholar
- Zawirska A, Adamski Z, Stawicka E, Schwartz RA. Cutaneous squamous cell carcinoma developing in lupus vulgaris exfoliativus persistent for 40 years. Int J Dermatol. 2009;48:125–7.View ArticlePubMedGoogle Scholar
- Lagerholm B, Skog E. Squamous cell carcinoma in psoriasis vulgaris. Three cases of squamous cell carcinoma developing in psoriatic lesions. Acta Derm Venereol. 1968;48:128–36.PubMedGoogle Scholar
- Sedira MA, Amin AA, Rifaat MA, et al. Locally advanced tumors of the scalp: the Egyptian National Cancer Institute experience. J Egypt Nat Cancer Inst. 2006;18:250–7.Google Scholar
- Wollina U, Bayyoud Y, Kronert C, Nowak A. Giant epithelial malignancies (basal cell carcinoma, squamous cell carcinoma): a series of 20 tumors from a single center. J Cutan Aesthet Surg. 2012;5:12–9.View ArticlePubMedPubMed CentralGoogle Scholar
- Ricci F, Paradisi A, Fossati B, et al. Giant neglected squamous cell carcinoma of the skin. Dermatol Ther. 2015;28:230–4.View ArticlePubMedGoogle Scholar
- Sratigos A, Garbe C, Lebbe C, Malvehy J, del Marmol V, Pehamberger H, et al. Diagnosis and treatment of invasive squamous cell carcinoma of the skin: European consensus-based interdisciplinary guideline. Eur J Cancer. 2015;51:1989–2007.View ArticleGoogle Scholar
- Breuninger H, Eigentler T, Bootz F, Hauschild A, Kortmann RD, Wolff K, et al. Brief S2k guidelines – Cutaneous squamous cell carcinoma. J Dtsch Dermatol Ges. 2013;11 Suppl 3:37–45. 39–47.View ArticlePubMedGoogle Scholar