Fig. 1
From: Dabrafenib in an elderly patient with metastatic melanoma and BRAF V600R mutation: a case report
Timeline. The black arrow represents time from diagnosis of metastatic disease until patient’s death. The orange arrow represents the duration of treatment with dabrafenib (7.1 months). Along the arrows, the − and + symbols represent the time points at which the plasma BRAFV600R mutation was negative and positive, respectively. a Initial CT scans (21 June 2013) showing hepatic (top) and pulmonary (bottom) lesions. b Representation of V600R mutation detected by Sanger sequencing. The black arrow points to the nucleotide changes. c Appearance of milium cysts (white arrow) secondary to dabrafenib treatment. d CT scans (8 January 2014) showing the radiological response is maintained after 5 months of treatment. The pictures correspond to the same lesions shown in a. e CT scans (17 March 2014) showing disease progression after 7.1 months of dabrafenib treatment. Top picture shows a new right adrenal mass and the bottom picture reveals the appearance of pericardial and pleural effusions. f Brain MRI showing multiple brain metastases (1 April 2014)