Alcoholic liver disease and bilateral multifocal central serous retinopathy: a case report
© Gkotsi et al.; licensee BioMed Central Ltd. 2013
Received: 4 June 2012
Accepted: 28 November 2012
Published: 13 February 2013
We present a unique case of a patient with bilateral, multifocal central serous retinopathy in a patient with alcoholic liver disease.
A 58-year-old Caucasian man with alcoholic liver disease, liver cirrhosis and ascites presented to the eye clinic. The ophthalmoscopic examination of both eyes revealed a symmetrical pattern of variably sized, slightly yellowish, translucent, raised lesions throughout the fundi which were confirmed to be caused by multifocal central serous retinopathy after optical coherence tomography and autofluoresence tests.
This case highlights the possible link between central serous retinopathy and end-stage liver disease, with potential implications for the pathogenesis of central serous retinopathy in these patients.
KeywordsAlcoholic liver disease Ascites Central serous retinopathy
Central serous retinopathy (CSR) is an exudative chorioretinopathy characterized by an exudative neurosensory retinal detachment with or without an associated detachment of the retinal pigment epithelium (RPE). It typically occurs in young, healthy adults and is usually idiopathic. The age range at the time of first diagnosis is generally from 22 to 83 years, and patients older than 50 years of age tend to have bilateral disease, systemic hypertension and a history of corticosteroid use . Rare variants of CSR with chronic, bilateral, extrafoveal, multifocal and bullous retinal detachments have also been observed in patients undergoing cardiac transplantation . Liver disease may be involved in sight-threatening eye diseases. The ophthalmic pathologies of cirrhosis in the literature include xerophthalmia, vitamin A deficiency and color blindness . Abe et al. found retinopathy with hemorrhages and exudates in 31.8% of patients with hepatitis C, irrespective of liver cirrhosis . According to Onder et al., retinopathy can be present not only in hepatitis C-positive patients but also in patients with other causes of liver cirrhosis, and soft exudates may develop in cirrhotic patients, probably due to loss of the synthetic function of the liver and the hemodynamic effects of portal hypertension . Haimovici et al. showed a statistically significant relationship between alcohol intake and CSR . Experimental studies have shown serous retinal detachment secondary to alteration of choroidal vascular permeability . One of the studies suggests that ischemia at the level of the choroid can cause capillary and venous congestion with increased fluid transudation . We report a unique case of bilateral multifocal CSR secondary to alcoholic chronic liver disease in a 58-year-old man.
A 58-year-old Caucasian man was referred to the eye clinic in view of multiple raised yellowish lesions in both fundi. He had originally visited his optician for occasional flashes and floaters. He had recently been diagnosed with diet controlled type 2 diabetes mellitus and was on a low dose of amlodipine (5mg/day) for well controlled hypertension. His other drug history included analgesics (paracetamol, dihydrocodeine) and omeprazole. He admitted to heavy alcohol consumption in the past and had chronic liver disease with ascites.
His examination revealed that he had hepatomegaly with a palpable liver edge three fingerbreadths below the right costal margin, but no splenomegaly. An ultrasound of the liver showed generally increased echogenicity suggestive of liver cirrhosis. A computed tomography (CT) scan confirmed the presence of liver cirrhosis and showed evidence of esophageal varices, in keeping with decompensated chronic liver disease.
There was no evidence of a localized lesion in the liver, ruling out the possibility of both hepatocellular carcinoma and metastatic disease as causes of decompensation. His liver function tests (LFTs), including alkaline phosphatase (ALP), alanine aminotransferase (ALT) and γ-glutamyl transferase (GGT), had been elevated for several years. Interestingly, he was also found to have a marginally elevated plasma viscosity of 1.81mPa/s (normal range 1.5 to 1.72mPa/s) with no evidence of paraprotein.
From a pathophysiological aspect, we hypothesize that in our patient the damaged liver produced less blood protein. This may have disturbed the body’s fluid balance, leading to alteration of choroidal vascular permeability, increased fluid transudation, serous fluid accumulation in the neurosensory retina and thus multifocal CSR . Ammonia dysmetabolism has also been noted in patients with liver cirrhosis. It is perhaps interesting to note that patients with minimal hepatic encephalopathy, despite their presenting with normal mental and neurological status upon clinical examination, have been found to demonstrate inflammation and raised levels of ammonia in the blood caused by diminished clearance by the liver . The increased serum levels of inflammatory markers (such as C-reactive protein, white blood cell count and IL-6) found in patients with liver cirrhosis  have been implicated in the breakdown of the blood–brain barrier. IL-6 and TNF-α are known to enhance fluid-phase permeability of isolated brain endothelial cells in vitro, suggesting that these and other inflammatory markers could also potentially contribute to changes in the outer blood–retina barrier and to an increase in choroidal vascular permeability, leading to CSR. Moreover, alcohol has been shown to be associated with nitric oxide–related abnormalities of choroidal blood flow autoregulation , thus providing an additional mechanism for the change in choroidal vascular permeability and the associated fluid leakage in the sub-RPE space and CSR development. Oxidative stress has also been implicated in liver cirrhosis . Enhanced production of reactive oxygen species is thought to be involved in the nitration of tyrosine residues in intracellular proteins, thus affecting transastrocytic substrate transport and selective degradation of the permeability of the blood–brain barrier and potentially the outer blood–retina barrier [12, 13].
To the best of our knowledge, this is the first case of multifocal CSR related to alcoholic liver disease to be reported in the literature and has potential implications for the pathogenesis of CSR in these patients. Our patient had no other risk factors for CSR , such as systemic steroid, antihistamine or antibiotic use; history of autoimmune disease; untreated hypertension; or tobacco use. The differential diagnoses of acute exudative polymorphous paraneoplastic vitelliform maculopathy  and acute exudative polymorphous vitelliform maculopathy  could not be excluded in the absence of fluorescein angiography and electroretinography, although the non-progressive nature of the lesions during follow-up in our patient, the absence of subretinal yellowish deposits gravitating as a meniscus below the macula, and the normal visual acuity were not supportive of these diagnoses.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
Central serous retinopathy
Liver function test
Optical coherence tomography
Retinal pigment epithelium
Tumor necrosis factor.
- Spaide RF, Campeas L, Haas A, Yannuzzi LA, Fisher YL, Guyer DR, Slakter JS, Sorenson JA, Orlock DA: Central serous chorioretinopathy in younger and older adults. Ophthalmology. 1996, 103: 2070-2080.View ArticlePubMedGoogle Scholar
- Friberg TR, Eller AW: Serous retinal detachment resembling central serous chorioretinopathy following organ transplantation. Graefes Arch Clin Exp Ophthalmol. 1990, 228: 305-309. 10.1007/BF00920052.View ArticlePubMedGoogle Scholar
- Onder C, Bengur T, Selcuk D, Bulent S, Belkis U, Ahmet M, Eser P, Leyla AS: Relationship between retinopathy and cirrhosis. World J Gastroenterol. 2005, 11: 2193-2196.View ArticlePubMedPubMed CentralGoogle Scholar
- Abe T, Nakajima A, Satoh N, Koizumi T, Sakuragi S, Ono T, Komatsu M, Masamune O: Clinical characteristics of hepatitis C virus-associated retinopathy. Jpn J Ophthalmol. 1995, 39: 411-419.PubMedGoogle Scholar
- Haimovici R, Koh S, Gagnon DR, Lehrfeld T, Wellik S: Central Serous Chorioretinopathy Case-Control Study Group. Risk factors for central serous chorioretinopathy: a case-control study. Ophthalmology. 2004, 111: 244-249. 10.1016/j.ophtha.2003.09.024.View ArticlePubMedGoogle Scholar
- Chon CH, Yao XY, Dalal R, Takeuchi A, Kim RY, Marmor MF: An experimental model of retinal pigment epithelial and neurosensory serous detachment. Retina. 1996, 16: 139-144.View ArticlePubMedGoogle Scholar
- Prünte C, Flammer J: Choroidal capillary and venous congestion in central serous chorioretinopathy. Am J Ophthalmol. 1996, 121: 26-34.View ArticlePubMedGoogle Scholar
- Shawcross DL, Wright G, Olde Damink SW, Jalan R: Role of ammonia and inflammation in minimal hepatic encephalopathy. Metab Brain Dis. 2007, 22: 125-138. 10.1007/s11011-006-9042-1.View ArticlePubMedGoogle Scholar
- Duchini A, Govindarajan S, Santucci M, Zampi G, Hofman FM: Effects of tumor necrosis factor-α and interleukin-6 on fluid-phase permeability and ammonia diffusion in CNS-derived endothelial cells. J Investig Med. 1996, 44: 474-482.PubMedGoogle Scholar
- Tittl MK, Spaide RF, Wong D, Pilotto E, Yannuzzi LA, Fisher YL, Freund B, Guyer DR, Slakter JS, Sorenson JA: Systemic findings associated with central serous chorioretinopathy. Am J Ophthalmol. 1999, 128: 63-68. 10.1016/S0002-9394(99)00075-6.View ArticlePubMedGoogle Scholar
- Wu D, Cederbaum AI: Oxidative stress and alcoholic liver disease. Semin Liver Dis. 2009, 29: 141-154. 10.1055/s-0029-1214370.View ArticlePubMedGoogle Scholar
- Murthy CR, Rama Rao KV, Bai G, Norenberg MD: Ammonia-induced production of free radicals in primary cultures of rat astrocytes. J Neurosci Res. 2001, 66: 282-288. 10.1002/jnr.1222.View ArticlePubMedGoogle Scholar
- Häussinger D, Schliess F: Pathogenetic mechanisms of hepatic encephalopathy. Gut. 2008, 57: 1156-1165. 10.1136/gut.2007.122176.View ArticlePubMedGoogle Scholar
- Grunwald L, Kligman BE, Shields CL: Acute exudative polymorphous paraneoplastic vitelliform maculopathy in a patient with carcinoma, not melanoma. Arch Ophthalmol. 2011, 129: 1104-1106. 10.1001/archophthalmol.2011.215.View ArticlePubMedGoogle Scholar
- Chan CK, Gass JD, Lin SG: Acute exudative polymorphous vitelliform maculopathy syndrome. Retina. 2003, 23: 453-462. 10.1097/00006982-200308000-00002.View ArticlePubMedGoogle Scholar
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