A case of eosinophilic esophagitis discovered with positron emission tomography imaging: a case report
© Haslem et al.; licensee BioMed Central Ltd. 2013
Received: 12 March 2013
Accepted: 31 May 2013
Published: 15 July 2013
Eosinophilic esophagitis was first reported in 1978, and since then it has been increasingly recognized as one of the major etiologies for dysphagia, food impaction, and food regurgitation. To the best of our knowledge, no case of eosinophilic esophagitis (excluding esophageal eosinophilia not responsive to proton pump inhibitor treatment) has previously been demonstrated on the basis of positron emission tomography imaging.
A 68-year-old Caucasian man presented with dysphagia to solids with recurrent regurgitation and weight loss of 7lb within the preceding 2 months. The patient attributed these symptoms to radiation therapy he had received 1 year earlier for squamous cell cancer of the lung. The patient underwent routine follow-up positron emission tomography imaging, which showed a hypermetabolic lesion in the posterior mediastinum and was increased at the level of the midesophagus.
To the best of our knowledge, this is the first reported case of eosinophilic esophagitis demonstrated by positron emission tomography imaging and confirmed with endoscopic evaluation and biopsies both after positron emission tomography imaging and a trial of proton pump inhibitor therapy. This could have an impact on the diagnostic evaluation of esophageal eosinophilic inflammation as well as eosinophilic infiltration of other gastrointestinal organs.
Eosinophilic esophagitis (EoE) was first reported by Landres et al. in 1978, and since then it has been increasingly recognized as one of the major etiologies for dysphagia, food impaction, and food regurgitation . Its prevalence is estimated to be 0.4% in an asymptomatic adult population . Among patients undergoing outpatient upper endoscopy for any indication, the prevalence of EoE varies between 5% to 16% and is highest in patients with dysphagia . The proposed diagnostic criteria for EoE includes more than 15 eosinophils per high-power field (HPF) in the esophageal epithelium. Although the true pathophysiology of EoE remains unknown, the literature has attributed the main etiology of EoE to allergic and genetic causes .
Although weight loss is not a common presenting symptom of patients with EoE, we believe that, due to weight gain along with alleviation of symptoms after induction of the combined treatment, it would be reasonable to assume that this was the cause of weight loss in our patient.
To the best of our knowledge, there is only one other report of EoE demonstrated by PET imaging and confirmed with endoscopic evaluation and biopsies . However, that report did not comment on proton pump inhibitor therapy (PPI) or other treatment prior to or at the time of follow-up after the PET scan. Therefore, it did not exclude PPI-responsive esophageal eosinophilia (PPI-REE).
In our patient, there was intense eosinophilia of the affected area of the midesophagus, with up to 80 eosinophils per HPF with repeat biopsies after 6wk of treatment showing more than 30 eosinophils per HPF. His history of long-term symptoms of dysphagia, which became more progressive, are typical of patients presenting with EoE. Previous reports have described CT findings of thickening of the esophagus related to EoE . It is likely that other inflammatory conditions of the esophagus would show similar results and could include infectious esophagitis, reflux esophagitis, malignancy, and others. Given the cost associated with PET-CT imaging and the broad differential of positive findings, we do not suggest that this modality has a primary role in diagnosing EoE at this time. However, it can potentially provide another diagnostic modality besides upper endoscopy. It may also provide information which could distinguish between PPI-REE and EoE, which could affect treatment decisions. More studies need to be done in this area, but in our patient the PET imaging demonstrated intense inflammation caused by eosinophilic infiltration which did not respond to PPI treatment.
Written informed consent was obtained from the patient’s spouse for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
We are grateful to our patient’s spouse, who agreed to the publication of this case report and provided all information needed.
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