Ultra late onset group B streptococcal sepsis with acute renal failure in a child with urethral obstruction: a case report
© Freudenstein et al; licensee BioMed Central Ltd. 2012
Received: 6 October 2011
Accepted: 20 February 2012
Published: 20 February 2012
Group B streptococci are a well-known cause of early and late onset sepsis. In neonates and older children gram-negative bacteria are mostly found in urinary tract infections and urosepsis. In adults predisposing factors for group B streptococci urinary tract infection may include diabetes mellitus and chronic renal failure.
We present a rare case of a five-month-old Caucasian boy with ultra late onset urosepsis and acute renal failure caused by group B streptococci serotype V. Excretion urography showed a subvesical obstruction that consequently was surgically corrected after antibiotic treatment of the acute infection.
Group B streptococci serotype V, urogenitary tract malformations, previous hospitalization and medical interventions may be important risk factors for the development of ultra late onset Group B streptococci sepsis in non-neonates.
KeywordsChildren urinary tract infection GBS late onset sepsis
Group B Streptococcus (GBS) is a leading cause of infection in newborns, pregnant women, and older persons with chronic medical illness. Cervicovaginal colonization with GBS in pregnant women can result in vertical transmission of GBS to neonates, with a limited number of GBS capsular serotypes being disproportionately associated with colonization and disease; serotypes Ia, III, and V, for example, cause the majority of invasive infections in older persons . Multiple serotypes of GBS also cause urinary tract infections (UTIs), which encompass asymptomatic bacteriuria, cystitis, pyelonephritis, urethritis, and urosepsis [1, 2]. GBS asymptomatic bacteriuria is particularly common among pregnant women; however, those most at risk for cystitis due to GBS are older persons and immunocompromised individuals [2, 3]. Predisposing factors for GBS UTI may include diabetes mellitus and chronic renal failure .
GBS infections in children have diverse clinical characteristics in patients with different ages at disease onset [5, 6]. While early-onset GBS sepsis is a well known cause of neonatal sepsis and meningitis, little information is available on GBS disease in children older than three months. Risk factors for sepsis caused by GBS in neonates are prematurity and preterm rupture of membranes. In non-newborns, babies with cardiovascular or urogenital abnormalities, vascular disease, neurological or immune deficiency are also prone to GBS infections [5, 6]. Here, we report on a five-month-old baby with an ultra-late onset urosepsis caused by GBS serotype V. In the literature, urinary tract infection and acute tonsillitis have rarely been described to be the clinical manifestation of GBS infection in children older than three months of age in Taiwan . Most cases of early and late onset sepsis including meningitis caused by GBS were caused by serotype III, followed by serotype Ia. Serotype V, which was isolated in our patient, was ranked third (6% of total isolates) in children with late onset sepsis . In adults, serotype V has been demonstrated to be the most common GBS serotype in urinary tract infections . Of note, a recent epidemiological study demonstrated a major impact of premature birth on ultra-late GBS meningitis in young babies . Children presenting with ultra-late onset sepsis, may be susceptible to GBS infection due to an underlying condition such as urogenital malformations. Apart from the colonization of the mothers, hospitalization and medical interventions may also be an important risk factor for the development of ultra-late onset sepsis [3, 5, 6]. In our case, the patient's mother tested GBS negative in a vaginal smear. Instead, iatrogenic GBS infection might have occurred after the recent hospitalization, where the child underwent herniotomy, orchidopexy, and bladder catheterization.
GBS may be a more common uropathogen in children than previously recognized. GBS serotype V, urogenitary tract malformations, previous hospitalization and medical interventions may be important risk factors for the development of ultra-late onset GBS sepsis in non-neonates. Prompt institution of therapy with antibiotics active against GBS following sensitivity studies could prevent systemic septic complications in this group of frail patients. Clearly, further studies are required to characterize the impact on pathogenicity and virulence of GBS in children and the epidemiology of such micro-organisms.
Written informed consent was obtained from the patient's next-of-kin for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Edwards MS, Baker CJ: Group B streptococcal infections in elderly adults. Clin Infect Dis. 2005, 41: 839-847. 10.1086/432804.View ArticlePubMedGoogle Scholar
- Lefebvre N, Forestier E, Mohseni-Zadehm M: Invasive Streptococcus agalactiae infections in non-pregnant adults. Med Mal Infect. 2007, 37: 796-801. 10.1016/j.medmal.2007.04.003.View ArticlePubMedGoogle Scholar
- Ulett KB, Benjamin WH, Zhuo F, Xiao M, Kong F, Gilbert GL, Schembri MA, Ulett GC: Diversity of Group B Streptococcus serotypes causing urinary tract infection in adults. J Clin Microbiol. 2009, 47: 2055-2060. 10.1128/JCM.00154-09.View ArticlePubMedPubMed CentralGoogle Scholar
- Munoz P, Coque T, Rodriguez Creixems M, Bernaldo de Quiros JC, Moreno S, Bouza E: Group B Streptococcus: a cause of urinary tract infection in nonpregnant adults. Clin Infect Dis. 1992, 14: 492-496. 10.1093/clinids/14.2.492.View ArticlePubMedGoogle Scholar
- Berardi A, Lugli L, Baronciani D, Creti R, Rossi K, Ciccia M, Gambini L, Mariani S, Papa I, Serra L, Tridapalli E, Ferrari F: GBS Prevention Working Group of Emilia-Romagna. Group B Streptococcal infections in a northern region of Italy. Pediatrics. 2007, 120: 487-493. 10.1542/peds.2006-3246.View ArticleGoogle Scholar
- Hussain SM, Luedtke GS, Baker CJ, Schlievert PM, Leggiadro RJ: Invasive group B streptococcal disease in children beyond early infancy. Pediatr Infect Dis J. 1995, 14: 278-281. 10.1097/00006454-199504000-00006.View ArticlePubMedGoogle Scholar
- Wu CS, Wang SM, Ko WC, Wu JJ, Yang YJ, Liu CC: Group B streptococcal infections in children in a tertiary care hospital in southern Taiwan. J Microbiol Immunol. 2004, Infect 37: 169-175.Google Scholar
- Fluegge K, Supper S, Siedler A, Berner R: Serotype distribution of invasive Group B streptococcal isolates in infants: results from a nationwide active laboratory surveillance study over 2 years in Germany. Clin Infect Dis. 2005, 40: 760-763. 10.1086/427942.View ArticlePubMedGoogle Scholar
- Guilbert J, Levy C, Cohen R, Bacterial Meningitis Group, Delacourt C, Renolleau S, Flamant C: Late and ultra late onset Streptococcus B meningitis: clinical and bacteriological data over 6 years in France. Acta Paediatr. 2010, 99: 47-51.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.