Lymphoepithelial carcinoma in the maxillary sinus: a case report
© Mohammed et al.; licensee BioMed Central Ltd. 2012
Received: 19 July 2012
Accepted: 10 October 2012
Published: 11 December 2012
Lymphoepithelial carcinoma of the maxillary sinus is a very rare malignancy and it can be difficult to make a pre-operative diagnosis.
A 72-year-old Caucasian woman presented to our facility with an isolated right-side epistaxis that had been present for three months, with the results of a computed tomography scan showing a soft tissue mass in the right maxillary sinus with an impacted tooth. The results of a transnasal endoscopic biopsy were compatible with a lymphoepithelial carcinoma, following which our patient underwent a radical excision of the mass. The final histology results revealed lymphoepithelial carcinoma of the maxillary sinus with negative assays for Epstein-Barr virus. Our patient was given post-operative external radiotherapy and has remained disease-free at three-year follow-up.
This report details the diagnosis and management of a case of lymphoepithelial carcinoma of the maxillary sinus, which is a very rare malignant tumor with very little mention in the literature. Only a strong suspicion with systematic use of various patho-immunological tests helps to arrive at a definitive diagnosis by excluding other better-known tumors.
KeywordsMaxillary sinus Lymphoepithelial carcinoma
A majority of malignant tumors of the paranasal sinuses occur in the maxillary sinus [1, 2]. Among malignant lesions of the maxillary sinus, lymphoepithelial carcinoma is very rare. Lymphoepithelial carcinoma is characterized by nests, sheets, or individual undifferentiated or poorly differentiated malignant epithelial cells surrounded and infiltrated by prominent components of small, mature lymphocytes and plasma cells . The more frequent sites of these tumors are the nasopharynx, salivary glands and the larynx . Very few cases of lymphoepithelial carcinoma arising in the maxillary sinus have been reported [5, 6] with none precisely detailing its diagnostic characteristics and management. In this report we present a case of maxillary sinus lymphoepithelial carcinoma and review the radiological findings, macroscopic and microscopic features, immunohistology and the treatment options available.
Lymphoepithelial carcinoma of the maxillary sinus is a very rare malignant tumor and was described for the first time by Schminke and Regaud in 1921 . The lymphoepithelial carcinoma frequently develops in the nasopharynx, salivary glands and the larynx. More rarely, it affects the lungs, esophagus, stomach, pancreas, skin, cervix, endometrium, vulva, kidney, bladder, and central nervous system . In the majority of cases, patients are asymptomatic, and the lesion is discovered incidentally by imaging . Otherwise, patients complain of non-specific sinonasal symptoms or may have obstructive nasal symptoms related to acute or chronic maxillary sinusitis  and rarely present with epistaxis, as in our patient. There is a strong association with an Epstein-Barr virus (EBV) infection . Interestingly, patients with lymphoepithelial carcinoma in Western Europe and the USA are usually Epstein-Barr virus negative . According to Lezzoni et al. the presence or absence of Epstein-Barr virus in the lymphoepithelial carcinoma of the maxillary sinus does not have any prognostic importance .
The lymphoepithelial carcinoma developing from the maxillary sinus can present as an aggressive tumor with signs of local invasion to nerves, orbit, or the rhinopharynx . In general, the routine laboratory tests are normal. In terms of imaging, the lymphoepithelial carcinoma of the maxillary sinus appears as a diffuse opacity of soft tissue density on standard radiography . Paranasal sinus CT scan highlights a solid homogenous mass occupying the maxillary sinus cavity that is not enhanced with an intravenous contrast injection . In our patient’s case, she had an impacted tooth inside the mass. There are no pathognomic radiological criteria that differentiate the lymphoepithelial carcinoma from other tumors of the maxillary sinus, especially squamous cell carcinomas or lymphomas. All these three tumors are locally destructive and have metastases to retropharyngeal and cervical nodes [11, 15]. In general, clinicoradiological tests are non-contributory to the final diagnosis. Histology and immunohistochemical analysis establish the definitive diagnosis of a lymphoepithelial carcinoma. The microscopic features of this tumor show epithelial cells with eosinophilic cytoplasm. Their large oval nuclei have fine vesicular chromatin with one to three prominent red nucleoli. The fibrous stroma is heavily infiltrated by plasma cells and lymphocytes. Immunohistochemical staining shows that epithelial cells of lymphoepithelial carcinoma stain positively for pancytokeratin marker (MNF 116) and MIB-1 and stain negatively for CK 5/6, CK 7, and CEA. There is no immune reactivity for melanin A marker and CK 20.
Because of the limited number of cases, there is no standardized treatment policy reported to date for lymphoepithelial carcinoma of the maxillary sinus . The initial treatment for maxillary sinus tumors has always been surgery. Lymphoepithelial carcinoma is known to be radiosensitive and hence we decided on a course of post-operative radiotherapy for our patient . Adjuvant chemotherapy and neck management has been suggested for advanced and extensive disease . Our patient did not receive any chemotherapy and neck management as she did not have neck metastasis. The rate of recurrence in maxillary sinus lymphoepithelial carcinoma is reported to be roughly 25 percent . A regular follow-up with periodic CT scans is recommended.
Lymphoepithelial carcinoma of the maxillary sinus is a very rare malignant tumor with little mention in the literature. Its pre-operative diagnosis is difficult and the final definitive diagnosis is established by histopathological examination and immunohistochemical studies. The treatment consists of surgery and radiotherapy with the possibility of achieving acceptable cure rates. A strong suspicion and systematic use of various immunological tests helps to arrive at a definitive diagnosis by excluding other better-known tumors.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review with the Editor-in-Chief of this journal.
We thank Ms. Aida and Mr. Oussama Darouichi for their help in the preparation of this article.
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