Table 2 Plasma pharmacokinetic parameters

Letrozole C_baseline (ng/mL)

0

106.9

0

76.1

Methadone

AUC_{0-24 h} (ng/hour/mL)

288.5

272.2

0.94

291.2

1857

6.4

AUC_inf (ng/hour/mL)

879.8

833.1

0.95

946.0

5674^a

6.0

Distribution T_1/2 (hour)

8.3

7.0

0.84

6.7

15.5

2.3

Elimination T_1/2 (hour)

48.5

50.4

1.0

52.4

52.4^a

1.0

Clearance (L/hour)

6.8

7.2

1.1

6.3

1.1^a

0.17

V_{d (extrap)} (L)

516.6

557.4

1.1

502.9

119.2^b

0.24

V_{d (area)} (L)

476.9

524.3

1.1

469.0

80.0^a

0.17

EDDP

AUC_{0-24 h} (ng/hour/mL)

29.2

26.9

0.92

28.2

217.6

7.7

Observed C_max (ng/mL)

1.6

1.3

0.81

1.6

10.5

6.6

AUC_methadone/AUC_{EDDP (0-12 h)}

12.3

13.6

1.1

12.6

11.6

0.92

AUC_methadone/AUC_{EDDP (0-24 h)}

9.9

10.1

1.0

10.3

8.5

0.83

EMDP

AUC_{0-24 h} (ng/hour/mL)

2.7

2.0

0.74

1.5

10.4

6.9

Observed C_max (ng/mL)

0.18

0.14

0.78

0.075

0.55

7.3