Inflammatory pseudotumors of the kidney and the lung presenting as immunoglobulin G4-related disease: a case report
© Nishikawa et al; licensee BioMed Central Ltd. 2011
Received: 15 February 2011
Accepted: 25 September 2011
Published: 25 September 2011
It has been reported that immunoglobulin G4-related systemic disease can spread to nearly every organ, and often presents as an inflammatory mass or masses at those sites. In the kidney, this disease is often diagnosed after a radical or partial nephrectomy following the discovery of an inflammatory mass which is often suspected to be a malignant tumor. Here, we present a rare case of inflammatory pseudotumors of the kidney and the lung presenting as immunoglobulin G4-related disease, which were diagnosed by computed tomography-guided biopsies.
A 54-year-old Japanese man was referred to our hospital with suspected bilateral renal cancer, multiple lung metastases and autoimmune pancreatitis. His serum immunoglobulin G4 level was high. We used computed tomography-guided biopsies and histopathological examinations of the biopsied specimens to diagnose the tumors as immunoglobulin G4-related bilateral renal and lung inflammatory pseudotumors. Our patient was treated with oral prednisolone, and after one month of treatment, contrast-enhanced computed tomography demonstrated a general improvement, as noted by a reduction in size of the masses.
Renal masses that are formed due to immunoglobulin G4-related disease require comprehensive diagnosis to prevent unnecessary surgical resections from being performed. Further consideration should be paid to immunoglobulin G4-related diseases in the future.
Patients with autoimmune pancreatitis often exhibit high serum immunoglobulin G4 (IgG4) levels, and/or marked infiltration of IgG4-positive plasma cells, both of which are hallmarks of IgG4-related systemic disease. In addition to the pancreas, IgG4-related mass-forming lesions have also been described in other organs. In the kidney, IgG4-related disease can also present as an inflammatory mass, and is often diagnosed after a radical or partial nephrectomy due to suspected malignancy. Here, we present a case report of a patient with IgG4-related bilateral renal and lung inflammatory pseudotumors. We also describe the diagnostic process and treatment course.
In 2001, Hamano et al. first reported that patients with autoimmune pancreatitis have high serum IgG4 levels and infiltration of IgG4-positive plasma cells . Subsequently, it was reported that several patients had developed mass-forming lesions in organs other than the pancreas. Thus, a novel disease entity was proposed and termed, 'IgG4-related systemic disease'. IgG is an immunoglobulin consisting of four subclasses (IgG1, IgG2, IgG3, and IgG4). IgG4 is the rarest IgG subclass in the serum, and accounts for 6% or less of total IgG. Zen et al. reported that Th2 cells are predominant in lesions of IgG4-related disease that are associated with an infiltration of numerous CD4- and CD25-positive regulatory T cells (Tregs). Furthermore, the authors found that interleukin-10 and tumor growth factor-β secreted from Tregs are involved in the proliferation of IgG4-positive plasma cells, excess IgG4 secretion, fibrosis and tumor formation .
IgG4-related systemic disease occurs more frequently in middle-aged and older men, with a male to female ratio of 2:1. The most common sites of occurrence are the pancreas and lung, but it can also occur in other tissues and organs including the common bile duct, salivary glands, kidney, prostate and retroperitoneum. In the kidney, IgG4-related disease sometimes manifests itself as tubulointerstitial nephritis, in which tumor formation is not a feature . A definitive diagnosis of these diseases requires histopathological evidence of inflammatory cell infiltration, particularly IgG4-positive plasma cells. Lynn et al. proposed that IgG4-related disease should be definitively diagnosed based on the presence of at least 30 cells/HPF of IgG4-positive plasma cells in a lesion . IgG4-related diseases also involve the formation of masses that are characterized by marked fibrosis and obliterating phlebitis.
It is important to differentiate these diseases from malignant tumors. To this end, for the diagnosis of autoimmune pancreatitis, the clinical diagnostic criteria were revised in 2006 to include high IgG4 levels and a mass-forming lesion outside the pancreas . There are no established guidelines regarding the treatment of IgG4-related systemic diseases, so we based our treatment on the Japanese consensus guidelines for the management of autoimmune pancreatitis, as recommended by the Japan Pancreas Society. Treatment was initiated with 0.6 kg/mg/day prednisolone, and the dose was tapered to 5 mg every one to two weeks according to the clinical symptoms and results upon examination or imaging. To prevent recurrence, maintenance doses of 5 mg were required for three years .
The renal and pulmonary masses in our patient were suspected to be bilateral renal cancer and multiple lung metastases. However, inflammatory pseudotumors could not be ruled out, because our patient also had autoimmune pancreatitis and high serum IgG and IgG4 levels. Therefore, a CT-guided biopsy and pathological examination were performed, leading to the diagnosis of IgG4-related disease. There are some reports of patients who presented with a renal mass, and thus underwent a nephrectomy as the mass was mistaken for a malignant tumor. Many of these patients were subsequently diagnosed with IgG4-related systemic disease by pathological examination [7, 8]. Since those patients did not have any clear symptoms aside from a renal mass, it seemed impossible to suspect IgG4-related disease based solely on imaging results. One reason for this may be that neither a definitive description of IgG4-related disease nor diagnostic criteria have been established. However, there are some types of prostatitis, idiopathic retroperitoneal fibrosis and renal masses that have been characterized as IgG4-related systemic diseases, and which are familiar to urologists.
We have presented a case of IgG4-related systemic disease characterized by masses in the kidney and lung, and diagnosed by CT-guided biopsy. Renal masses in particular require comprehensive diagnosis so that unnecessary surgical resection can be avoided. Further emphasis should be placed on the study of IgG4-related diseases in the future.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
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