Successful treatment of a T4 lung tumor with vertebral body invasion using fiducial markers in the thoracic spine for image-guided radiation therapy: A case report
© Jain et al; licensee BioMed Central Ltd. 2011
Received: 27 April 2011
Accepted: 20 September 2011
Published: 20 September 2011
Paravertebral and paraspinal tumors pose a significant challenge in radiation therapy because of the radiation sensitivity of the spinal cord and the need for maximum treatment accuracy. Implantation of fiducial markers into vertebral bodies has been described as a method of increasing the accuracy of radiation treatment for single-dose stereotactic radiosurgery for spinal and paraspinal primary tumors and metastases. However, utilization of this technique has not been described for conventionally fractionated radiation therapy. This report is the first of its kind in the literature and describes successful treatment of a T4 primary lung tumor with vertebral body invasion with conventionally fractionated, image-guided radiotherapy using fiducial markers implanted in the thoracic spine.
Our patient was a 47-year-old African-American man who presented to our hospital with a history of several months of increasing left arm pain, chest pain, dyspnea on exertion, occasional dry cough, and weight loss. He was found to have stage IIIA T4, N0, M0 lung cancer with vertebral body invasion. He had fiducial markers placed in the thoracic spine for image-guided radiation treatment set-up. The patient received 74 Gy radiation therapy with concurrent chemotherapy, and daily matching of the fiducial markers on the treatment machine allowed for treatment of the tumor while sparing the dose to the adjacent spinal cord. With one year of clinical follow-up, the patient has had regression of the tumor with only asymmetric soft-tissue thickening seen on a computed tomographic scan and grade 1 dyspnea on exertion as the only side effects of the treatment.
Fiducial marker placement is a safe and effective technique for maximizing the accuracy and reproducibility for radiation treatment of lesions near the spinal cord. This technique may be used in conventionally fractionated radiation treatment regimens, such as those employed to treat a lung tumor with vertebral body invasion, to potentially improve clinical outcomes for patients.
The radiation tolerance of the spinal cord has traditionally been a dose-limiting factor in the treatment of spinal and paraspinal lesions. Intensity-modulated radiation therapy (IMRT) planning has the ability to achieve concave dose distributions that provide spinal cord sparing even if the target lesion is only millimeters away . However, these treatment plans have very steep dose gradients, so a very high degree of precision is needed during radiation delivery. Even very slight set-up errors may result in significant deviation of delivery of the planned dose .
Fiducial marker matching is a method of image-guided radiation therapy (IGRT) used to maximize set-up accuracy. Radiopaque markers are implanted in or near the tumor site and can be imaged on the treatment machine and matched to the digitally reconstructed radiograph (DRR) from the planning computed tomography (CT) scan. The majority of published data regarding fiducial markers in the spine have pertained to methods used in stereotactic radiosurgery [3–5]. Our case report describes the application of this technique for conventionally fractionated radiation treatment of a lung tumor. The application of IGRT using fiducial markers in the spine in our patient allowed for radiation treatment of primary lung cancer with vertebral body invasion while limiting the radiation dose to the adjacent spinal cord.
Our patient was a 47-year-old man who presented to our hospital with a history of several months of increasing left arm pain, chest pain, dyspnea on exertion, occasional dry cough, and a 2.3 kg weight loss over the course of the preceding three months. A physical examination showed 4 of 5 weakness of the left upper extremity but no other abnormalities.
The patient was diagnosed with stage IIIA T4, N0, M0 lung cancer on the basis of the AJCC Cancer Staging Manual, Seventh Edition, staging system criteria . He was offered enrollment in Radiation Therapy Oncology Group (RTOG) protocol 0617, and he consented. He was randomized to receive 74 Gy of radiation therapy using conventional daily fractions of 2 Gy with concurrent carboplatin and paclitaxel, followed by consolidation carboplatin and paclitaxel.
The patient underwent CT simulation for radiation therapy planning with the use of a custom Alpha Cradle foam mold and wingboard (Smithers Medical Products, Inc., North Canton, OH, USA) Verified for immobilization. CT scans of the patient were taken during inspiration, expiration, and free breathing. CT simulation images were fused with PET images to aid in target delineation. Gross tumor volume was outlined during inspiration, expiration, and free breathing scanning and fused to form an integrated target volume. A margin of expansion of 5 mm was used to create a clinical target volume (CTV). An additional expansion of 5 mm was used to create a planning target volume (PTV). The CTV and PTV margins were decreased in the areas of bone to limit microscopic disease extension and organ motion in this area.
Daily shifts at treatment set-up (in centimeters)
0 to 0.7
0.4 to 1.3
0.3 to 1.0
The patient developed improvement in left arm pain and strength three weeks into radiation treatment. He developed grade 2 esophagitis toward the end of radiation treatment, which was controlled with diet modification and sucralfate as needed. His esophagitis resolved four weeks after treatment was completed.
IGRT has emerged as a method of improving radiation treatment accuracy for tumors near the spinal cord. Three forms of IGRT for this purpose have been described in the literature: cone-beam CT (CBCT), KV X-ray imaging, and fiducial marker matching.
CBCT involves use of a CT scan that can be taken on the treatment machine. The tumor volume or normal structures on the CBCT scan are then matched with the treatment-planning CT scan, and appropriate shifts can be made. Kim et al.  used CBCT to set up single-fraction stereotactic body radiotherapy for spinal treatments and found that it provided precise target localization with accuracy within 2 mm.
KV X-ray imaging involves the use of orthogonal X-ray images that can be taken in the treatment room. These images have a higher resolution than traditionally used megavoltage (MV) images and allow for matching of patient anatomy to bony landmarks on a DRR. Yin et al.  at Henry Ford Hospital have used KV X-ray imaging with anatomy matching to vertebral bodies for intensity-modulated spinal radiosurgery and found that patient motion could be reduced to within 3 mm when coupled with good immobilization.
Fiducial markers have been used successfully in spinal radiosurgery at a number of institutions, including the University of Pittsburgh  and Stanford University . The implantation of markers involves an invasive procedure with associated risk. Gerstzen et al.  reported a series of spinal radiosurgery procedures where fiducial tracking was used in 30 cases, and they reported one durotomy secondary to the marker implant procedure. Movement, or migration of markers, can also interfere with the use of fiducial markers for accurate treatment set-up. Shirato et al.  reported marker migration in one of three patients who underwent transcutaneous insertion of spinal markers for radiotherapy.
However, there are data suggesting that there may be increased accuracy of fiducial markers with the use of other forms of IGRT. Watchman et al.  compared KV X-ray imaging and fiducial marker matching for the set-up of 18 treatment fractions of stereotactic spinal radiotherapy. They found that matching to implanted markers was consistently more accurate, by approximately 0.5 mm, which also led to significant sparing of the spinal cord dose.
The case of our patient shows an extension of this technique from stereotactic radiosurgery to conventionally fractionated radiation therapy. Patients who have spinal or paraspinal tumors who are not candidates for radiosurgery because of tumor factors such as large tumor size or other clinical reasons (such as indications for concurrent chemotherapy) may benefit from the use of spinal fiducial markers for conventionally fractionated radiation therapy.
Fiducial marker placement is a safe and effective technique for maximizing the accuracy and reproducibility of radiation treatment to lesions near the spinal cord. The procedure can be performed on an out-patient basis and with little discomfort to the patient. This technique can be used in combination with IMRT in conventionally fractionated radiation therapy to potentially improve clinical outcomes for patients.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Yamada Y, Lovelock DM, Bilsky MH: A review of image-guided intensity-modulated radiotherapy for spinal tumors. Neurosurgery. 2007, 61: 226-235. 10.1227/01.NEU.0000279970.10309.B5.View ArticlePubMedGoogle Scholar
- Guckenberger M, Meyer J, Wilbert J, Baier K, Bratengeier K, Vordermark D, Flentje M: Precision required for dose-escalated treatment of spinal metastases and implications for image-guided radiation therapy (IGRT). Radiother Oncol. 2007, 84: 56-63. 10.1016/j.radonc.2007.05.021.View ArticlePubMedGoogle Scholar
- Gerszten PC, Burton SA: Clinical assessment of stereotactic IGRT: spinal radiosurgery. Med Dosim. 2008, 33: 107-116. 10.1016/j.meddos.2008.02.003.View ArticlePubMedGoogle Scholar
- Ryu SI, Chang SD, Kim DH, Murphy MJ, Le QT, Martin DP, Adler JR: Image-guided hypo-fractionated stereotactic radiosurgery to spinal lesions. Neurosurgery. 2001, 49: 838-846.PubMedGoogle Scholar
- Gerszten PC, Ozhasoglu C, Burton SA, Kalnicki S, Welch WC: Feasibility of frameless single-fraction stereotactic radiosurgery for spinal lesions. Neurosurg Focus. 2002, 13: e2-View ArticlePubMedGoogle Scholar
- Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A, eds, The American Joint Committee on Cancer (AJCC): AJCC Cancer Staging Manual. 2010, New York: Springer, 7Google Scholar
- Kim S, Jin H, Yang H, Amdur RJ: A study on target positioning error and its impact on dose variation in image-guided stereotactic body radiotherapy for the spine. Int J Radiat Oncol Biol Phys. 2009, 73: 1574-1579. 10.1016/j.ijrobp.2008.12.023.View ArticlePubMedGoogle Scholar
- Yin FF, Ryu S, Ajlouni M, Yan H, Jin JY, Lee SW, Kim J, Rock J, Rosenblum M, Kim JH: Image-guided procedures for intensity-modulated spinal radiosurgery. Technical note. J Neurosurg. 2004, 101 (Suppl 3): 419-424.PubMedGoogle Scholar
- Shirato H, Harada T, Harabayashi T, Hida K, Endo H, Kitamura K, Onimaru R, Yamazaki K, Kurauchi N, Shimizu T, Shinohara N, Matsushita M, Dosaka-Akita H, Miyasaka K: Feasibility of insertion/implantation of 2.0-mm-diameter gold internal fiducial markers for precise setup and real-time tumor tracking in radiotherapy. Int J Radiat Oncol Biol Phys. 2003, 56: 240-247. 10.1016/S0360-3016(03)00076-2.View ArticlePubMedGoogle Scholar
- Watchman CJ, Hamilton RJ, Stea B, Mignault AJ: Patient positioning using implanted gold markers with the Novalis Body system in the thoracic spine. Neurosurgery. 2008, 62 (5 Suppl): A62-A68.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.