A giant adrenal pseudocyst presenting with right hypochondralgia and fever: a case report
© Momiyama et al; licensee BioMed Central Ltd. 2011
Received: 3 July 2010
Accepted: 4 April 2011
Published: 4 April 2011
Adrenal pseudocysts are rare cystic masses that arise from the adrenal gland and which are usually non-functional and asymptomatic. Adrenal pseudocysts consist of a fibrous wall without an epithelial or endothelial lining. We report the case of a patient with a giant adrenal pseudocyst presenting with right hypochondralgia and high fever.
A 52-year-old Japanese man was admitted with right hypochondralgia and a chill. Abdominal computed tomography revealed a well-defined cystic mass measuring 19 cm which was located in the right adrenal region and the contents of which were not enhanced with contrast medium. Abdominal ultrasonography revealed a heterogeneously hypo-echoic lesion with a peripheral high-echoic rim. Serum hormonal levels were almost normal. Despite treatment with antibiotics, the high fever persisted. Based on these findings, we made a preoperative diagnosis of a right adrenal cyst with infection. However, the possibility of malignancy still remained. The patient underwent laparotomy and right adrenal cyst excision with partial hepatectomy in order to relieve the symptoms and to confirm an accurate diagnosis. Histological examination revealed an adrenal pseudocyst with infection. His condition improved soon after the operation.
We report a case of a giant adrenal pseudocyst with infection. Surgery is required for symptomatic cases in order to relieve the symptoms and in cases of uncertain diagnosis.
In 1903, Doran attributed the first case of adrenal cyst to Greiselius . In 1670, he described a 45-year-old man whose death resulted from a rupture of the cyst. There were only seven cases of adrenal cyst reported by 1906. Wahl questioned the rarity of adrenal cysts in 1951 and found an autopsy incidence of 1 in 1555 . The paucity of reports in the literature was a manifestation of clinical silence rather than true rarity. In 1966, Foster described 220 cases of adrenal cyst in the world's literature , while in 1979 Incze et al. reported 250 cases .
Cystic lesions of the adrenal gland are uncommon and demonstrate a spectrum of histological changes and may vary from pseudocysts to malignant cystic neoplasms. An adrenal pseudocyst is a fibrous-surrounded cyst within the adrenal gland devoid of a recognizable layer of lining cells. The incidence of adrenal pseudocyst with infection is very rare. Only a few cases have been found in the MEDLINE database search with 'adrenal pseudocyst' and 'infection' so far. We report a case of giant adrenal pseudocyst presenting with a right hypochondralgia and high fever, which was diagnosed as an adrenal pseudocyst with infection measuring about 19 cm in largest diameter.
Adrenal cysts are rare and the documented incidence varies between 0.064% and 0.18% in autopsy series . However, the rate of detection of adrenal cysts has risen dramatically due to the more frequent use of CT and MRI imaging studies in recent years, which account for approximately 5% of incidentally discovered adrenal lesions . Adrenal cysts may occur at any age but most are found in the 3rd to 5th decades . In some series, a female preponderance of about 3:1 has been noted for unknown reasons .
Histologically, cystic formations of the adrenals are divided into four groups: parasitic; epithelial (true cysts); endothelial (vascular cysts with an endothelial lining); and pseudocysts . There are also other more infrequent subtypes such as lymphangiomas, mesothelial cysts, dermoid cysts or cystic adrenal carcinomas. Adrenal pseudocysts represent approximately 80% of cystic adrenal masses [9, 10]. Adrenal pseudocysts are devoid of an epithelial or endothelial lining, arise within the adrenal gland and are surrounded by a fibrous tissue wall.
The true origin of adrenal pseudocyst remains a mystery. One theory suggests that these lesions result from an intra-adrenal hemorrhage caused by trauma, a sepsis event or some other form of shock . The initial injury leads to the development of a cavity with a scarred, fibrous lining that slowly enlarges over time. Another theory suggests that these lesions are true cysts that have lost their cellular lining because of the inflammation and bleeding within the cyst. The etiology of our patient's pseudocyst seemed to be similar to latter theory. The patient's lesion was diagnosed as a true cyst at first because of its homogeneity on the US finding. The internal structure of the cyst changed into heterogeneous and, finally, the cyst was diagnosed as pseudocyst.
Most adrenal cysts are asymptomatic because of their small size . In the case of large cysts, symptoms occur in relation to their compression of adjacent organs. This seems to be a common feature in most pseudocysts (either they arise from the adrenals or from the pancreas) and seems to be related to the chronically increased intra-abdominal pressure that these cyst introduce . The three most prominent clinical features are: a dull pain in the adrenal area; gastrointestinal symptoms; and a palpable mass. They seldom cause adrenal hypofunction, Cushing's syndrome or pheochromocytoma . Acute abdomen or a tender mass may occasionally be found, when intracystic hemorrhage, rupture or infection occurs . Our patient had a right hypochondralgia with tenderness and high fever due to infection, with no gastrointestinal complaints. He had no hypertension during the follow-up period.
Due to the wide use of the diagnostic imaging modalities, the detection rate of adrenal cystic lesions is increasing. However, a preoperative confirmatory diagnosis of a large adrenal cyst can be very difficult because of the indistinct boundary with surrounding organs and adhesion to neighboring organs. Furthermore, even with integrated fluorine-18 fluorodeoxyglucose positron emission tomography (PET), adrenal lesions may be identified as false-positive at PET, including adrenal adenomas, adrenal endothelial cysts and inflammatory and infectious lesions .
The differential diagnosis of adrenal pseudocysts includes splenic, hepatic and renal cysts, as well as mesenteric or retroperitoneal cysts, urachal cysts and solid adrenal tumors. An exact diagnosis is clinically important in large lesion because adrenal incidentalomas larger than 5 cm  carry an increased risk of adrenal malignancy. The reported incidence of malignancy in adrenal cystic lesions is approximately 7% .
On CT, most pseudocysts demonstrate well-demarcated round or oval masses with fluid density but the CT features of pseudocysts are more complicated than simple cysts due to the complicated components such as septa, blood and soft-tissue components. The cysts wall shows occasional calcification. MRI is the best modality for visualizing the complicated intracystic components. Moreover, MRI is particularly sensitive for detecting intracystic hemorrhage, which shows hyperintense on both T1- and T2-weighted images.
Treatment of adrenal cysts is determined by size and the symptoms related to the mass. Surgical excision is indicated by the presence of symptoms, a suspicion of malignancy and an increase in size, or the detection of, a functioning adrenal cyst. Surgical treatment may not be necessary for small asymptomatic lesions as most cysts are benign . If the adrenal lesion is diagnosed as a simple nonfunctioning cyst, the patient may be treated conservatively with aspiration alone. In large abscesses, where the probability of rupture is increased, transcutaneous drainage should be avoided as it may increase the risk of microbial load dissemination .
An adrenal pseudocyst is an uncommon clinical finding and is even rarer when it is giant-sized and infected. Surgery is required for symptomatic cases in order to relieve the symptoms and in cases of uncertain diagnosis. Radiological and clinical features of the tumor are nonspecific, thus, histopathological examination is essential in order to establish a definitive diagnosis.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
magnetic resonance imaging
positron emission tomography
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