Open Access
Open Peer Review

This article has Open Peer Review reports available.

How does Open Peer Review work?

Volcano-like intermittent bleeding activity for seven years from an arterio-enteric fistula on a kidney graft site after pancreas-kidney transplantation: a case report

  • Peter Härle1Email author,
  • Stephan Schwarz2,
  • Julia Langgartner3,
  • Jürgen Schölmerich3 and
  • Gerhard Rogler4
Journal of Medical Case Reports20104:357

DOI: 10.1186/1752-1947-4-357

Received: 21 December 2009

Accepted: 8 November 2010

Published: 8 November 2010



We report the first case of a patient who underwent simultaneous kidney and pancreas transplantation and who then suffered from repeated episodes of severe gastrointestinal bleeding over a period of seven years. Locating the site of gastrointestinal bleeding is a challenging task. This case illustrates that detection of an arterio-enteric fistula can be very difficult, especially in technically-challenging situations such as cases of severe intra-abdominal adhesions. It is important to consider the possibility of arterio-enteric fistulas in cases of intermittent bleeding episodes, especially in transplant patients.

Case presentation

A 40-year-old Caucasian man received a combined pancreas-kidney transplantation as a result of complications from diabetes mellitus type I. Thereafter, he suffered from intermittent clinically-relevant episodes of gastrointestinal bleeding. Repeat endoscopic, surgical, scintigraphic, and angiographic investigations during his episodes of acute bleeding could not locate the bleeding site. He finally died in hemorrhagic shock due to arterio-enteric bleeding at the kidney graft site, which was diagnosed post-mortem.


In accordance with the literature, we suggest considering the removal of any rejected transplant organs in situations where arterio-enteric fistulas seem likely but cannot be excluded by repeat conventional or computed tomography-angiographic methods. Arterio-enteric fistulas may intermittently bleed over many years.


We report the case of a 40-year-old Caucasian man who had undergone simultaneous kidney and pancreas transplantation and who suffered from repeated severe gastrointestinal bleeding episodes over a period of seven years. Locating a gastrointestinal bleeding site is a challenging task. It is important to consider the possibility of arterio-enteric fistulas in cases of intermittent bleeding episodes, especially in transplant patients. To the best of our knowledge, it has not been previously described in the literature that an arterio-enteric fistula can intermittently be active over seven years and not be detected despite repeated and intense conservative and surgical diagnostic procedures.

Case presentation

A 40-year-old Caucasian man was referred to our intensive care unit for further diagnostic work-up because of gastrointestinal bleeding of unknown location. After blood transfusions in the referring hospital, he presented with a hemoglobin level of 12.3 mg/dL at 3:45 pm.

In March 1997, he received a simultaneous pancreatic-duodenal transplantation connected to the right iliac artery and renal transplantation connected to the left iliac artery on the basis of long-standing diabetes mellitus type I. The transplantation procedure was more difficult due to abdominal adhesions caused by peritoneal dialysis over five years with recurrent bacterial peritonitis. Two episodes of hemoglobin-relevant bleeding occurred; the first five days after the transplantation and the second 14 days after. These were followed by surgical revisions of the severe adhesive abdomen without finding the bleeding site. In April 1998, July 1998, February 1999, and August 1999 acute and hemoglobin-relevant gastrointestinal bleeding episodes occurred. Repeated gastroscopy and colonoscopy, in addition to conventional and magnetic resonance (MR)-angiographies, and repeat exploratory surgeries with intra-operative endoscopies in cooperation with skilled endoscopists and Tc-erythrocyte scintigraphies, could not reveal the location of the bleeding. The renal graft lost function due to rejection in August 1998. In June 1999, he received a second renal graft on his left side, leaving the first kidney graft in place. The second renal graft also lost function due to rejection in April 2003 and hemodialysis was started in October 2003. The pancreas graft lost function in 2002 due to rejection.

At about 10 pm on the day of his admission to our unit, he complained of severe, colic-like diffuse abdominal pain. An ultrasound did not show cholelithiasis, kidney or bladder problems and an X-ray of the chest and abdomen did not show any air-fluid levels. Administration of butyl-scopalamine relieved the colic-like pain completely. At 2 am, in a routine blood-gas check, his hemoglobin was down to 7.9 mg/dL and two units of blood were transfused with adequate rise to 9.4 mg/dL after one unit of blood. At 5 am, he again complained of severe colic-like diffuse abdominal pain with nausea, tachycardia, and hypotension. His hemoglobin levels dropped to 5.7 mg/dL without showing bloody stools. Intravenous fluids, blood transfusions and catecholamines were administered immediately. Suddenly, he vomited massive amounts of blood mixed with large blood clots, making intubation impossible. He died of hemorrhagic shock.

Autopsy revealed extensive intra-abdominal adhesions. Meticulous exploration by the pathologist finally revealed an arterio-enteric fistula between his left common iliac artery, where the initial kidney was engrafted, and the adjacent ileum (Figure 1[A, B]). In addition, large blood clots were found distal to the fistula in his small intestine which led to intestinal obstruction; explaining the eruptive vomiting of blood instead of showing bloody stools. The obstruction with intestinal distension might also explain the colic-like pain [1] which was alleviated after administration of butyl-scopalamine.
Figure 1

(A) Anatomic situation of the aorta with left common iliac vein, artery, and arterio-enteric fistula to the ileum. (B) Bloody residues are seen in the lumen of the ileum with fistula to the left common iliac artery.


Significant bleeding from an arterio-enteric fistula after pancreas transplantation is rare and associated with a high mortality rate [2]. In the literature, bleeding episodes are described in the setting of the context of pancreatitis of the transplanted organ and rejection reactions [1, 3, 4]. These inflammatory processes in close proximity to arterial vessels and the gut are likely to present the driving forces for the development of arterio-enteric fistula. Occurrences of arterio-enteric fistulas have also been described in other settings such as following pelvic radiation [5], aorto-iliac operations [68], biliary wallstent implantation [9], gastrointestinal and graft infections [1012], spontaneously [6], and in chronic inflammatory bowel disease [13]. Emergency angiography with endovascular repair seems to be effective in controlling the acute bleeding situation [8, 14, 15]. However, a high rate of rebleeding is described and surgical removal of the transplanted pancreas showed the best survival outcome in the cases presented in the literature [1, 2]. We describe for the first time that an arterio-enteric fistula can be intermittently active over seven years and not be detected despite repeated and intense conservative and surgical diagnostic procedures. Astonishingly, our case report stabilized after each acute bleeding episode, probably due to thrombotic occlusion of the fistula, making it impossible to detect it by surgery, endoscopic, angiographic, and scintigraphic methods. In our case report, the first bleeding episode occurred five days after his initial simultaneous pancreas-kidney transplantation. Rejection or pancreatitis as the cause of the fistula development was unlikely to have played a role during the first bleeding episode, as described in the above-mentioned transplant literature cases. Finally, it should be considered in our case report that there were severe abdominal adhesions caused by multiple bacterial peritonitis episodes during peritoneal dialysis prior to his first transplantation, thus enhancing the chance for surgical complications. In the follow-up period, the intra-abdominal adhesions were becoming increasingly problematic, giving the surgeons, the endoscopists, and finally the pathologist a challenge when inspecting our patient's intestine and organ graft sites.


Retrospectively, we think that in renal and pancreatic transplant patients with gastrointestinal bleeding of obscure origin, even some years after transplantation after years, there should be a high suspicion for arterio-enteric fistulas. Therefore, we think that for these patients conventional- or computed tomography (CT)-angiography of the vascular insertion regions needs to be strongly suggested, repeatedly if necessary, to find the source of this bleeding [16, 17].

However, in the case of inconclusive severe gastrointestinal bleeding, despite repetitive conventional or CT-angiographic examinations, it might be worth considering the removal of a rejected kidney along with the connecting vessels because arterio-enteric fistulas may be very difficult or even impossible to detect despite using the whole arsenal of medical diagnostics [18].


Written informed consent was obtained from the patient's next-of-kin for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.


Authors’ Affiliations

Klinik für Rheumatologie und Physikalische Therapie, Katholisches Klinikum Mainz
Institute of Pathology, University of Regensburg
Department of Internal Medicine I, University of Regensburg
Department of Internal Medicine, University of Zürich


  1. Higgins PD, Umar RK, Parker JR, DiMagno MJ: Massive lower gastrointestinal bleeding after rejection of pancreatic transplants. Nat Clin Pract Gastroenterol Hepatol. 2005, 2: 240-244. 10.1038/ncpgasthep0175. quiz 1 p following 244View ArticlePubMedGoogle Scholar
  2. Leonhardt H, Mellander S, Snygg J, Lönn L: Endovascular management of acute bleeding arterioenteric fistulas. Cardiovasc Intervent Radiol. 2008, 31: 542-549. 10.1007/s00270-007-9267-3.View ArticlePubMedGoogle Scholar
  3. Fellmer P, Lanzenberger K, Ulrich F, Pascher A, Langrehr J, Jonas S, Kahl A, Frei U, Neuhaus P, Pratschke J: Complication rate of pancreas retransplantation after simultaneous pancreas-kidney transplantation compared with pancreas after kidney transplantation. Transplant Proc. 2007, 39: 563-564. 10.1016/j.transproceed.2006.12.003.View ArticlePubMedGoogle Scholar
  4. Lopez NM, Jeon H, Ranjan D, Johnston TD: Atypical etiology of massive gastrointestinal bleeding: arterio-enteric fistula following enteric drained pancreas transplant. Am Surg. 2004, 70: 529-532.PubMedGoogle Scholar
  5. Kwon TH, Boronow RC, Swan RW, Hardy JD: Arterio-enteric fistula following pelvic radiation: a case report. Gynecol Oncol. 1978, 6: 474-478. 10.1016/0090-8258(78)90058-6.View ArticlePubMedGoogle Scholar
  6. Gozzetti G, Poggioli G, Spolaore R, Faenza A, Cunsolo A, Selleri S: Aorto-enteric fistulae: spontaneous and after aorto-iliac operations. J Cardiovasc Surg (Torino). 1984, 25: 420-426.Google Scholar
  7. Robertson GA, Valente JF, Hunter GC, Bernhard VM, Putnam CW: Iliac-enteric fistula following Dacron patch angioplasty. Ann Vasc Surg. 1991, 5: 467-469. 10.1007/BF02133054.View ArticlePubMedGoogle Scholar
  8. Burks JA, Faries PL, Gravereaux EC, Hollier LH, Marin ML: Endovascular repair of bleeding aortoenteric fistulas: a 5-year experience. J Vasc Surg. 2001, 34: 1055-1059. 10.1067/mva.2001.119752.View ArticlePubMedGoogle Scholar
  9. Gardiner MF, Long WB, Haskal ZJ, Lichtenstein GR: Upper gastrointestinal hemorrhage secondary to erosion of a biliary Wallstent in a woman with pancreatic cancer. Endoscopy. 2000, 32: 661-663. 10.1055/s-2000-4662.View ArticlePubMedGoogle Scholar
  10. Mir N, Edmonson R, Yeghen T, Rashid H: Gastrointestinal mucormycosis complicated by arterio-enteric fistula in a patient with non-Hodgkin's lymphoma. Clin Lab Haematol. 2000, 22: 41-44. 10.1046/j.1365-2257.2000.00264.x.View ArticlePubMedGoogle Scholar
  11. Umpleby HC, Britton DC, Turnbull AR: Secondary arterio-enteric fistulae: a surgical challenge. Br J Surg. 1987, 74: 256-259. 10.1002/bjs.1800740411.View ArticlePubMedGoogle Scholar
  12. Gutowski P: [Aortoiliac graft infection as a diagnostic and treatment problem]. Ann Acad Med Stetin. 1998, 1-72. (in Polish), Suppl 41
  13. Kim JH, Kim WH, Choi CH, Choi SH, Jeon TJ, Kim TI, Kim NK, Kim HG: A case of Crohn's disease with iliac arterio-enteric fistulae. Korean J Gastroenterol. 2003, 42: 77-80. (in Korean)PubMedGoogle Scholar
  14. McBeth BD, Stern SA: Lower gastrointestinal hemorrhage from an arterioenteric fistula in a pancreatorenal transplant patient. Ann Emerg Med. 2003, 42: 587-591. 10.1067/S0196-0644(03)00388-3.View ArticlePubMedGoogle Scholar
  15. Semiz-Oysu A, Cwikiel W: Endovascular management of acute enteric bleeding from pancreas transplant. Cardiovasc Intervent Radiol. 2007, 30: 313-316. 10.1007/s00270-006-0058-z.View ArticlePubMedGoogle Scholar
  16. Rajan R, Dhar P, Praseedom RK, Sudhindran S, Moorthy S: Role of contrast CT in acute lower gastrointestinal bleeding. Dig Surg. 2004, 21: 293-296. 10.1159/000080204.View ArticlePubMedGoogle Scholar
  17. Duchesne J, Jacome T, Serou M, Tighe D, Gonzales A, Hunt JP, Marr AB, Weintraub SL: CT-angiography for the detection of a lower gastrointestinal bleeding source. Am Surg. 2005, 71: 392-397.PubMedGoogle Scholar
  18. Baird RL, Slagle GW, Boggs HW: Arterio-enteric fistulas. Dis Colon Rectum. 1979, 22: 187-188. 10.1007/BF02586819.View ArticlePubMedGoogle Scholar


© Härle et al; licensee BioMed Central Ltd. 2010

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.