Oral lesions are well-documented clinical features in patients with Crohn's disease (CD) [1–4]. The spectrum of these lesions described so far in the medical and dental literature is quite large and includes oral ulceration, labial, buccal and gingival swelling, buccal abscesses, mucosal inflammatory hyperplasia, mucosal tags and fissuring, gingivitis, granulomatous inflammation of minor salivary glands, granulomatous cheilitis [5–10], candidiasis, angular cheilitis, lichen planus, pyostomatitis vegetans, lymphadenopathy, perioral erythema, orofacial granulomatosis, midline lip fissuring, cobblestone appearance of the mucosa, and dental caries. The prevalence of oral lesions in newly diagnosed patients has been estimated to be up to 48% .
It is of interest that, like other extraintestinal manifestations, oral lesions may precede the onset of the underlying intestinal inflammatory disorder [3, 7, 8]. However, it is difficult to determine exactly which oral manifestation is certainly related to CD although it is logical to hypothesize that some of these lesions are in fact consequence of the disease or a secondary reaction to medical treatment.
Orofacial granulomatosis is a term used to describe swelling of the orofacial area, mainly the lips, secondary to an underlying granulomatous inflammatory process. Granulomatous cheilitis is the histopathological description of such inflammation occurring in the lips and surrounding tissues [5, 8, 9]. It has been recognized as an early manifestation of CD following, coinciding with or preceding the onset of CD [7, 8]. This extraintestinal manifestation could significantly affect the quality of life of patients with CD.
Therefore, the aim of this presentation is to describe the long-term clinical course of the underlying CD in relation to the clinical behavior of the oral lesion in different time periods.