Table 1 Substances used in intradermal testing

1

Levemir ^© (insulin glargine, m-cresol, glycerol)

+

++

++

2

Huminsulin basal ^© (human insulin, m-cresol, phenol, glycerol, protamine)

+

++

++

3

Lantus ^© (insulin glargine, m-cresol, glycerol)

+

++

++

4

Actrapid penfill ^© (human insulin, m-cresol, glycerol)

+

++

++

5

Insuman rapid ^© (human insulin, m-cresol)

+

++

++

6

Berlinsulin H normal ^© (human insulin, phenol, protamine, glycerol)

+

++

++

7

Insulin Novo semilente ^© (porcine insulin, methyl-4-hydroxybenzoate, natrium acetate)

+

++

++

8

Humalog ^© (insulin lispro, m-cresol, glycerol, NaH₂PO₄ × H₂O, zinc oxide)

+

+

+

9

Novorapid ^© (insulin aspart, glycerol, m-cresol, phenol, NaH₂PO₄ × H₂O)

+

+

+

10

Apidra ^© (insulin glulisine, m-cresol, trometamol, polysorbate 20)

+

+

+

11

Test solution A (NaH₂PO₄ × H₂O 2.1 mg, glycerol 85% 18.8 mg, phenol 0.6 mg, m-cresol 1.5 mg in aqua dest. ad 1.0 ml)

-

-

-

12

Test solution B (glycerol 85% 18.8 mg, phenol 0.6 mg, m-cresol 1.5 mg in aqua dest. ad 1.0 ml)

-

-

-

13

Test solution C (phenol 0.6 mg, m-cresol 1.5 mg in aqua dest. ad 1.0 ml)

+

-

-

14

Test solution D (phenol 0.6 mg in aqua dest. ad 1.0 ml)

+

-

-

15

Test solution E (m-cresol 1.5 mg in aqua dest. ad 1.0 ml)

+

-

-

16

Test solution F (protamine 0.1 mg, NaH₂PO₄ × H₂O 2.1 mg, glycerol 85% 18.8 mg, phenol 0.6 mg, m-cresol 1.5 mg in aqua dest. ad 1.0 ml)

+

++

++

17

Test solution G (protamine 0.1 mg in aqua dest. ad 1.0 ml)

-

++

++

18

Test solution H (zinc chloride 0.06 mg, glycerol 85% 20 mg, m-cresol 2.7 mg in aqua dest. ad 1.0 ml)

-

-

-

19

Test solution I (glycerol 85% 20 mg, m-cresol 2.7 mg in aqua dest. ad 1.0 ml)

-

-

-

20

Test solution J (m-cresol 2.7 mg in aqua dest. ad 1.0 ml)

-

-

-

21

Aqua dest.

-

-

-

22

NaCl 0.9%

-

-

-

23

Histamine 0.01%

+

-

-