Pulmonary fibrosis secondary to siderosis causing symptomatic respiratory disease: a case report
© McCormick et al; licensee BioMed Central Ltd. 2008
Received: 23 June 2007
Accepted: 05 August 2008
Published: 05 August 2008
Pulmonary siderosis secondary to the inhalation of iron compounds is a rare condition which, despite striking radiological and histopathological features, has not traditionally been associated with symptoms or functional impairment. Although not the first of its kind, we present an unusual case of pulmonary siderosis with symptomatic respiratory disease, most likely secondary to associated fibrosis.
A 66-year-old Caucasian man was referred to the outpatient clinic with a 2-year history of exertional breathlessness. He had worked as an engineer for 20 years where he did a significant amount of welding but always wore a face shield. Clinical, radiological and histological features were consistent with a diagnosis of pulmonary siderosis, with associated fibrosis, most likely related to his occupational welding history.
Our report illustrates that symptomatic respiratory disease due to mild peribronchiolar fibrosis can occur with pulmonary siderosis despite wearing a mask. Furthermore, it reinforces the need for all clinicians to compile a detailed occupational history in individuals presenting with breathlessness.
Pulmonary siderosis secondary to the inhalation of iron compounds is a rare condition which was first described in 1936 . Despite striking radiological and histopathological features, it has traditionally been classified as a 'benign pneumoconiosis'  because of the absence of associated symptoms, functional impairment or pulmonary fibrosis . Uncommonly, however, symptomatic disease with interstitial fibrosis has been described in arc welders . We present an unusual case of pulmonary siderosis with symptomatic respiratory disease, most likely secondary to associated fibrosis.
A 66-year-old Caucasian man was referred to the outpatient clinic with a 2-year history of exertional breathlessness. He had no other respiratory symptoms, had never smoked and was not aware of any previous asbestos exposure. He was not on any medication and had no allergies. He had worked as an engineer for 20 years where he did a significant amount of welding but always wore a face shield. A review of systems was unremarkable.
Inhalation of iron compounds occurs commonly in paint factories, during welding and steelmaking, and at various stages of iron mining and iron refining. Doig and McLaughlin first described 'welders' siderosis' in 1936 when they carried out a prospective study examining the clinical and chest radiological characteristics of 16 electric arc welders . All but one of these original subjects were followed for 9 years: four of these demonstrated progressive radiographic reticular changes, nine showed no radiographic changes, and in two men (both of whom had spent significantly less time welding), there was evidence of at least partial resolution of the initial radiographic opacities . All subjects, however, remained in good health, leading to the conclusion that siderosis (in its pure form) was not associated with respiratory symptoms or functional impairment. This view was supported by subsequent pathological investigations of the lungs of subjects occupationally exposed to iron oxide fumes, which did not demonstrate any evidence of pulmonary fibrosis . As a result, the apparently inert nature of iron compounds led to the classification of pulmonary siderosis as a 'benign pneumoconiosis' .
Nevertheless, symptomatic disease with interstitial fibrosis has been described in arc welders . Some authors have postulated that these rare cases are secondary to concomitant inhalation of silicates or asbestos that can occur in many occupations associated with exposure to iron . However, Funahashi et al. challenged this view after investigating 10 symptomatic welders and performing energy dispersive X-ray analysis on lung tissue for elemental content . Despite demonstrating restrictive defects in seven of their patients, and mild to moderate airway obstruction in a further two, they found no difference between the pulmonary silicon content of patients with symptomatic 'welders' pneumoconiosis' and that of age-matched control lungs . Some degree of parenchymal fibrosis was present in all patients, and in 50%, this fibrosis was considered moderate to marked. As many of the iron-containing particles were seen in fibrotic alveolar septa, it was postulated that the fibrosis was a reaction to these particles rather than the co-existing silicosis .
Our report illustrates that symptomatic respiratory disease due to mild peribronchiolar fibrosis can occur with pulmonary siderosis despite wearing a mask. Furthermore, it reinforces the need to compile a detailed occupational history in individuals with respiratory disease. It is particularly important to obtain an accurate diagnosis of interstitial shadowing on chest radiograph as pulmonary siderosis in our patient had a relatively good prognosis compared with other interstitial and small airway disorders.
Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
forced expiratory volume in 1 second
total lung capacity
- Doig AT, McLaughlin AIG: X-ray appearances of the lungs of electric arc welders. Lancet. 1936, 1: 771-775. 10.1016/S0140-6736(00)56868-8.View ArticleGoogle Scholar
- Billings CG, Howard P: Occupational siderosis and welders' lung: a review. Monaldi Arch Chest Dis. 1993, 48: 304-314.PubMedGoogle Scholar
- Doig AT, McLaughlin AIG: Clearing of X-ray shadows in welders' siderosis. Lancet. 1948, 1: 789-791. 10.1016/S0140-6736(48)90858-7.View ArticlePubMedGoogle Scholar
- Nemery B: Metal toxicity and the respiratory tract. Eur Respir J. 1990, 3: 202-219.PubMedGoogle Scholar
- Funahashi A, Schlueter DP, Pintar K, Bemis EL, Siegesmund KA: Welders' pneumoconiosis: tissue elemental microanalysis by energy dispersive X-ray analysis. Br J Ind Med. 1988, 45: 14-18.PubMedPubMed CentralGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.