Ruptured ovarian cystic teratoma in pregnancy with diffuse peritoneal reaction mimicking advanced ovarian malignancy: a case report
© Maiti et al; licensee BioMed Central Ltd. 2008
Received: 09 September 2007
Accepted: 12 June 2008
Published: 12 June 2008
This case illustrates the unusual complication of granulomatous peritonitis following rupture of a dermoid cyst in pregnancy resembling disseminated ovarian carcinoma. To the best of the authors' knowledge, this is the first report of this complication during advanced pregnancy in the literature.
A dermoid cyst ruptured during surgical removal in the second trimester of pregnancy in a 27-year-old primigravida. Postoperatively the patient suffered pulmonary embolism and leakage of sebaceous material through the abdominal wound. She gradually developed significant abdominal distension, gastrointestinal symptoms and lost more than 8 kg of weight in the 12 weeks postoperatively. The baby was delivered at 31 weeks by a technically challenging caesarean section owing to severe dense adhesions obscuring the uterus. Bowel resection was performed for suspected malignant infiltration and adhesion causing obstruction. She had a protracted convalescence with an ileostomy and mucus fistula. Histology confirmed granulation without malignancy. One year following the surgical treatment, she had recovered well and was planning her next pregnancy.
Although granulomatous peritonitis following rupture of a dermoid cyst is very rare, awareness is the key to diagnosis and appropriate management. Per-operative frozen section may be helpful.
Mature cystic teratoma (dermoid cyst) is one of the most common benign ovarian neoplasms discovered during pregnancy (24–40%) [1, 2]. They may be responsible for complications such as torsion, rupture and obstruction during labour. Rupture is rare, but once it has occurred it can cause complications such as chemical or granulomatous peritonitis mimicking advanced ovarian malignancy [3–5]. This case illustrates the unusual complication of granulomatous peritonitis following rupture of a dermoid cyst in pregnancy resembling disseminated ovarian carcinoma. To the best of the authors' knowledge, this is the first report of this complication during advanced pregnancy in the literature.
A magnetic resonance imaging (MRI) scan showed a collection of fluid occupying the POD and subsequently a subcutaneous collection was found during an ultrasound scan. She was treated with antibiotics empirically. Seven weeks following her initial surgery, she developed painful induration of the wound. She underwent wound exploration that revealed copious, thick, sebaceous-type material tracking extra-peritoneally up to the costal margin and umbilicus. Bacterial culture was again reported to be negative.
She developed dependent oedema, abdominal distension, intermittent vomiting and significant weight loss despite advancing pregnancy. In view of the patient's continuing deterioration and significant psychological distress, it was decided to deliver the baby.
Over the following six weeks (one year after her initial surgery), her condition improved both physically and mentally. The inflammatory markers returned to normal. She is presently thinking about going back to work and the possibility of conceiving again.
The word teratoma is derived from the Greek word teraton, meaning monster, and was used initially by Virchow in the first edition of his book on tumours, which was published in 1863 (see ). Since mature cystic teratomas are composed of all three germ cell layers, the term 'dermoid' is a misnomer. Mature cystic teratomas are thought to arise from primordial germ cells. This theory is supported by the distribution of these tumours along the lines of migration from the yolk sac to the primitive gonad. The majority of these tumours occur during the reproductive years providing further support for the germ cell theory . Benign cystic teratoma (BCT) is the most common benign ovarian neoplasm comprising 10–15% of all ovarian tumours. It occurs at all stages of life, the majority of cases being diagnosed between 20 and 30 years of age . This fact makes it the most common tumour during pregnancy (22–40% of all ovarian tumours) . In pregnancy the risk of complications increases significantly including rupture, torsion, infection and malignant degeneration. As BCT has a tendency to remain in the confines of the true pelvis, it could lead to dystocia and obstructed labour . Treatment is surgical removal as soon as possible after diagnosis to avoid complications. Ovarian cystectomies or oophorectomies via laparoscopy or laparotomy are options depending on the situation and expertise available. All efforts should be made to avoid rupture or leakage of cyst fluid during the operation. If it happens before or during the operation, copious saline washing should be performed to minimise chemical peritonitis and its sequelae [3, 7, 8]. When BCT is found incidentally in the first trimester of pregnancy, surgical removal should be performed at 14–16 weeks of gestation to avoid the risk of damage to the corpus luteum. If diagnosis of BCT occurs at 16–22 weeks, surgery should be performed as soon as possible. If it is first discovered after 22 weeks of pregnancy, the treatment may be deferred until delivery . Over 200 cases of BCT in pregnancy have been reported in the literature and many of them ruptured spontaneously or iatrogenically. In a review of 47 cases, Kocak et al  reported that during cyst extraction, minimal spillage occurred in 42.5% of cases and none developed chemical peritonitis.
Clement et al  and Achtari et al  reported chemical peritonitis following cystic fluid spillage. The patients needed further surgeries to treat the complications. Two other case reports by Suprasert et al  and one by Phupong et al  reported a diffuse peritoneal reaction mimicking advanced ovarian malignancy where full surgical staging was performed. Postoperative histological examination revealed BCT and chronic granulomatous peritonitis. A conservative approach was adopted and patients were free of symptoms without further treatment at 12 months [1, 5]. The incidence of chemical peritonitis after rupture and leakage of cystic fluid in the peritoneum is less than 0.5% (see ). The incidence of chronic granulomatous peritonitis after rupture or leakage of cystic fluid is also extremely rare. In granulomatous peritonitis after ruptured ovarian teratomas, numerous nodules of mature glial tissue implant on a widespread area of the peritoneum .
Ruptured BCT of the ovary mimicking gynaecological malignancy is uncommon and could be misdiagnosed . Intra-abdominal peritoneal seedlings, adhesions and/or masses are frequent sequelae. In most such cases, abdominal seedlings are essentially of mature neuroglial elements and long-term survival rate is good. Recognition of a dermoid tumour associated with glial seedling is important to avoid unnecessary debulking surgery. Following postoperative adhesions, fibrous bands or obstructions, conservative management seems to have a good prognosis.
Although granulomatous peritonitis following rupture of a dermoid cyst is very rare, awareness is the key to diagnosis and appropriate management. Peroperative frozen section may be helpful. Optimal management avoids unnecessary repeated major surgeries and provides a good long-term outcome with minimal complications.
Written informed consent was obtained from the patient for publication of this case report. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
The authors wish to express their gratitude to the patient Ms CS.
- Comerci JT, Licciardi F, Bergh PA, Gregori C, Breen JL: Mature cystic teratoma: a clinicopathologic evaluation of 517 cases and review of the literature. Obstet Gynecol. 1994, 84: 22-28.PubMedGoogle Scholar
- Peterson WF, Prevost EC, Edmunds FT, Hundley JM, Morris FK: Benign cystic teratomas of the ovary; a clinico-statistical study of 1,007 cases with a review of the literature. Am J Obstet Gynecol. 1955, 70: 368-382.PubMedGoogle Scholar
- Stuart GC, Smith JP: Ruptured benign cystic teratomas mimicking gynecologic malignancy. Gynecol Oncol. 1983, 16: 139-143. 10.1016/0090-8258(83)90019-7.View ArticlePubMedGoogle Scholar
- Suprasert P, Khunamornpong S, Siriaunkgul S, Phongnarisorn C, Siriaree S: Ruptured mature cystic teratomas mimicking advanced stage ovarian cancer: a report of 2 cases study. J Med Assoc Thai. 2004, 87 (12): 20041522-1525.Google Scholar
- Phupong V, Sueblinvong T, Triratanachat S: Ovarian teratoma with diffused peritoneal reactions mimicking advanced ovarian malignancy. Arch Gynecol Obstet. 2004, 270: 189-191. 10.1007/s00404-003-0479-8.View ArticlePubMedGoogle Scholar
- Cade D, Ellis H: The peritoneal reaction to starch and its modification by prednisone. Eur Surg Res. 1976, 8: 471-479. 10.1159/000127891.View ArticlePubMedGoogle Scholar
- Clement D, Barranger E, Benchimol Y, Uzan S: Chemical peritonitis: a rare complication of an iatrogenic ovarian dermoid cyst rupture. Surg Endosc. 2003, 17: 658-10.1007/s00464-002-4272-8.View ArticlePubMedGoogle Scholar
- Achtari C, Genolet PM, Bouzourene H, De Grandi P: Chemical peritonitis after iatrogenic rupture of a dermoid cyst of the ovary treated by coelioscopy. Apropos of a case and review of the literature. Gynakol Geburtshilfliche Rundsch. 1998, 38 (3): 146-150. 10.1159/000022253.View ArticlePubMedGoogle Scholar
- Kocak M, Dilbaz B, Ozturk N, Dede S, Altay M, Dilbaz S, Haberal A: Laparoscopic management of ovarian dermoid cysts: a review of 47 cases. Ann Saudi Med. 2004, 24: 357-360.PubMedGoogle Scholar
- Ronnett BM, Seidman JD: Mucinous tumors arising in ovarian mature cystic teratomas: relationship to the clinical syndrome of pseudomyxomaperitonei. Am J Surg Pathol. 2003, 27: 650-657. 10.1097/00000478-200305000-00008.View ArticlePubMedGoogle Scholar
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