External beam irradiation of myocardial carcinoid metastases: a case report
© Strosberg et al; licensee BioMed Central Ltd. 2007
Received: 15 May 2007
Accepted: 19 September 2007
Published: 19 September 2007
The heart is an exceedingly rare site of metastatic involvement in carcinoid tumors. Only nineteen cases have been described in the literature over the past 30 years. We report here on a patient who presented with progressive carcinoid syndrome despite surgical resection of her liver metastases. She was found to have cardiac metastases on inidium-111-pentetreotide scintigraphy and subsequently underwent external beam radiation to the heart resulting in symptomatic palliation of her syndrome and objective radiographic response. To our knowledge, this is the first reported case of metastatic cardiac carcinoid treated with external beam irradiation.
A 45 year-old woman with a history of metastatic carcinoid disease presented to our institution with progressive flushing and diarrhea.
She had been diagnosed with a carcinoid tumor 18 months earlier when an enlarged mesenteric lymph node was discovered incidentally during laparoscopic gastric bypass surgery. Pathologic evaluation demonstrated a moderately differentiated neuroendocrine tumor. Laboratory studies revealed an elevation in 24 hour urine 5 hydroxyindoleacetic acid (5HIAA) of 37.4 mg (reference range 1–6 mg) and an elevated serum serotonin of 1671 ng/ml (reference range 22–180 ng/ml). At the time of initial diagnosis, the patient denied any prior history of flushing, diarrhea or wheezing.
Depot octreotide therapy was initiated, and a series of three laparoscopic hepatic radiofrequency ablations were performed over the ensuing 6 months. Although this therapy resulted in normalization of the 24-hour urine 5-HIAA, serum serotonin remained elevated (539 ng/ml). Moreover, the patient began developing progressive diarrhea and intense facial flushing despite dose escalation of depot octreotide from 30 mg to 60 mg every 4 weeks.
Repeat indium-111-pentetreotide scintigraphy twelve months after initial diagnosis demonstrated resolution of activity in the liver. However, persistent radiotracer uptake was detected in the region of the myocardium. Echocardiography was ordered to evaluate for the presence of cardiac metastases. It demonstrated trace to mild tricuspid insufficiency and trace aortic insufficiency, but showed no evidence of an intracardiac mass.
Although right sided heart valve fibrosis and dysfunction is a hallmark of carcinoid heart disease, myocardial metastases from carcinoid tumors are distinctly uncommon. Among 243 patients undergoing echocardiography for evaluation for carcinoid heart disease, sonographic evidence of cardiac tumor was observed in only 6 patients (2%). Another series of 132 patients undergoing echocardiograms for evaluation of carcinoid heart disease demonstrated a 4% rate of myocardial metastases.
While echocardiography has been the primary technique for identifying myocardial metastases from carcinoid tumors, other methods have also been described in the literature. Puvaneswary et al. described the use of magnetic resonance imaging for localization of cardiac metastases, while Yeung et al. reviewed the use of 111Indium-pentetreotide scintigraphy. In this case, scintigraphy demonstrated radiotracer uptake in the region of the heart while MRI scans provided important anatomic information enabling use of focused radiation therapy. Echocardiography, however, failed to accurately identify the cardiac tumors.
The location of cardiac metastases in prior reported cases has included all chambers of the heart as well as pericardium.[1, 2, 5, 6] Two patients presented with malignant arrhythmias, including one patient who developed fatal bradycardia due to tumor infiltration of the atrioventricular node. Carcinoid syndrome associated with elevation in urine 5HIAA has been documented in the majority of cases described in the literature.
An interesting feature of this case was the persistence of elevated serotonin along with progressive flushing and diarrhea despite the successful resection of liver metastases through radiofrequency ablation and normalization of urine 5 hydroxyindolacetic acid (5HIAA). Since inactivation of serotonin and its catabolism into 5HIAA occurs partially in the lung, we hypothesize that the direct secretion of serotonin into the systemic circulation by the left ventricular metastasis may have resulted in exacerbation of the carcinoid syndrome despite ablation of liver metastases.
Surgical resection of cardiac metastases has been the therapy of choice in the majority of carcinoid tumors described in the literature.[1, 2, 4] A minority of cases were treated with systemic chemotherapy. The use of external beam irradiation for control of cardiac metastases from carcinoid tumors has not been described in the literature but there have been single institutional series reporting the effectiveness of radiation for other sites of metastatic disease.
Schupak and Wallner reviewed 44 patients with metastatic or unresectable carcinoid tumors who were treated at Memorial Sloan-Kettering Cancer Center with radiation. The sites included in their series were epidural space, brain, bone, and abdomen. Infield control following radiotherapy was 77% for epidural sites and 78% for bone sites. No patient with brain metastasis had progression of intracranial disease after radiation and 80% of patients with abdominal disease achieved a complete or partial response. The authors did not demonstrate a dose response relationship and recommended 45–50 Gy in 4–5 weeks for non-hepatic sites. Chakravarthy and Abrams reported on 18 patients with metastatic or unresectable carcinoid patients at Johns Hopkins. In their series, clinical improvement occurred in 87% of the sites irradiated.
Cardiac effects of radiation have been evaluated in great detail, with data derived largely from follow-up of long term survivors of Hodgkin's disease. Current evidence has shown that radiation to the heart can be associated with pericardial disease, accelerated atherogenesis of the coronary arteries, myocardial disease, valve defects, and predisposition to conduction abnormalities.[10–13]
The heart is a rare site of involvement in metastatic carcinoid tumors. Electrocardiogram-gated MRI may be a useful imaging modality for anatomic delineation of the tumor. Carcinoid tumors involving the myocardium can produce substantial morbidity due to invasion of sensitive cardiac structures and also due to secretion of serotonin directly into the systemic circulation. When surgical resection is considered excessively risky, external beam irradiation may be an effective option for palliation of symptoms. The potential benefits need to be weighed against the risks of pericardial, valvular and myocardial toxicity as well as chronic atherogenesis.
Written patient consent was obtained for publication of this report.
- Pandya UH, Pellikka PA, Enriquez-Sarano M, Edwards WD, Schaff HV, Connolly HM: Metastatic carcinoid tumor to the heart: echocardiographic-pathologic study of 11 patients. J Am Coll Cardiol. 2002, 40 (7): 1328-1332. 10.1016/S0735-1097(02)02109-5.View ArticlePubMedGoogle Scholar
- Pellikka PA, Tajik AJ, Khandheria BK, Seward JB, Callahan JA, Pitot HC, Kvols LK: Carcinoid heart disease. Clinical and echocardiographic spectrum in 74 patients. Circulation. 1993, 87 (4): 1188-1196.View ArticlePubMedGoogle Scholar
- Puvaneswary M, Thomson D, Bellamy GR: Cardiac metastasis from carcinoid tumour: magnetic resonance imaging findings. Australas Radiol. 2004, 48 (3): 383-387. 10.1111/j.0004-8461.2004.01323.x.View ArticlePubMedGoogle Scholar
- Yeung HW, Imbriaco M, Zhang JJ, Macapinlac H, Goldsmith SJ, Larson SM: Visualization of myocardial metastasis of carcinoid tumor by indium-111-pentetreotide. J Nucl Med. 1996, 37 (9): 1528-1530.PubMedGoogle Scholar
- Drake WM, Jenkins PJ, Phillips RR, Lowe DG, Grossman AB, Besser GM, Wass JA: Intracardiac metastases from neuroendocrine tumours. Clin Endocrinol (Oxf). 1997, 46 (4): 517-522. 10.1046/j.1365-2265.1997.1440958.x.View ArticleGoogle Scholar
- Rich LL, Lisa CP, Nasser WK: Carcinoid pericarditis. Am J Med. 1973, 54 (4): 522-527. 10.1016/0002-9343(73)90048-X.View ArticlePubMedGoogle Scholar
- Shehata BM, Thomas JE, Doudenko-Rufforny I: Metastatic carcinoid to the conducting system-is it a rare or merely unrecognized manifestation of carcinoid cardiopathy?. Arch Pathol Lab Med. 2002, 126 (12): 1538-1540.PubMedGoogle Scholar
- Schupak KD, Wallner KE: The role of radiation therapy in the treatment of locally unresectable or metastatic carcinoid tumors. Int J Radiat Oncol Biol Phys. 1991, 20 (3): 489-495.View ArticlePubMedGoogle Scholar
- Chakravarthy A, Abrams RA: Radiation therapy in the management of patients with malignant carcinoid tumors. Cancer. 1995, 75 (6): 1386-1390. 10.1002/1097-0142(19950315)75:6<1386::AID-CNCR2820750622>3.0.CO;2-U.View ArticlePubMedGoogle Scholar
- Stewart JR, Fajardo LF: Dose response in human and experimental radiation-induced heart disease. Application of the nominal standard dose (NSD) concept. Radiology. 1971, 99 (2): 403-408.View ArticlePubMedGoogle Scholar
- Carmel RJ, Kaplan HS: Mantle irradiation in Hodgkin's disease. An analysis of technique, tumor eradication, and complications. Cancer. 1976, 37 (6): 2813-2825. 10.1002/1097-0142(197606)37:6<2813::AID-CNCR2820370637>3.0.CO;2-S.View ArticlePubMedGoogle Scholar
- Hancock SL, Tucker MA, Hoppe RT: Factors affecting late mortality from heart disease after treatment of Hodgkin's disease. Jama. 1993, 270 (16): 1949-1955. 10.1001/jama.270.16.1949.View ArticlePubMedGoogle Scholar
- Adams MJ, Lipshultz SE, Schwartz C, Fajardo LF, Coen V, Constine LS: Radiation-associated cardiovascular disease: manifestations and management. Semin Radiat Oncol. 2003, 13 (3): 346-356. 10.1016/S1053-4296(03)00026-2.View ArticlePubMedGoogle Scholar
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